Microfluidic Generation of Near-Infrared Photothermal Vitexin/ICG Liposome with Amplified Photodynamic Therapy.

Humans Indocyanine Green / chemistry Liposomes / chemistry Photochemotherapy / methods Microfluidics Glioma / drug therapy Proto-Oncogene Proteins c-bcl-2 Cell Line, Tumor
indocyanine green lab-on-a-chip liposome near-infrared ray vitexin

Journal

AAPS PharmSciTech
ISSN: 1530-9932
Titre abrégé: AAPS PharmSciTech
Pays: United States
ID NLM: 100960111

Informations de publication

Date de publication:
22 Mar 2023
Historique:
received: 13 12 2022
accepted: 12 02 2023
entrez: 23 3 2023
pubmed: 24 3 2023
medline: 25 3 2023
Statut: epublish

Résumé

Glioma, in which a malignant tumor cell occurs in neural mesenchymal cells, has a rapid progression and poor prognosis, which is still far from desirable in clinical treatments. We developed a lab-on-a-chip (LOC) device for the rapid and efficient preparation of vitexin/indocyanine green (ICG) liposomes. Vitexin could be released from liposome to kill cancer cell, which can potentially improve the glioma therapeutic effect and reduce the treatment time through synergistic photodynamic/photothermal therapies (PDT/PTT). The vitexin/ICG liposome was fabricated via LOC and its physicochemical property and release in vitro were evaluated. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method and live/dead staining were used to examine the enhanced antitumor effect of vitexin/ICG liposome in cooperation with PDT/PTT, while the related mechanism was explored by flow cytometry and western blot. The results were as follows: (1) The prepared vitexin/ICG liposome was smaller in size, homogenous in particle size distribution with significant low polydispersity index (PDI), and enhanced cumulative release in vitro. (2) We found that the formulated liposome presented strong cancer cell inhibition and suppression of its migration in a dose-dependent manner. (3) Further mechanistic studies showed that liposome combined with near-infrared irradiation could significantly upregulate levels of B cell lymphoma 2-associated X (Bax) protein and decrease B cell lymphoma 2 (Bcl-2) at protein levels. The vitexin/ICG liposomes prepared based on a simple LOC platform can effectively enhance the solubility of insoluble drugs, and the combined effect of PTT/PDT can effectively increase their antitumor effect, which provides a simple and valid method for the clinical translation of liposomes.

Identifiants

DOI: 10.1208/s12249-023-02539-2 PMID: 36949351
pubmed: 36949351
doi: 10.1208/s12249-023-02539-2
pii: 10.1208/s12249-023-02539-2
doi:

Substances chimiques

Indocyanine Green IX6J1063HV
Liposomes 0
vitexin 9VP70K75OK
Proto-Oncogene Proteins c-bcl-2 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

82

Subventions

Organisme : National Key R&D Program of China
ID : 2018YFE0208600
Organisme : Key planning social development projects of Zhenjiang in Jiangsu Province
ID : SH2021024
Organisme : National Natural Science Foundation of China
ID : 81720108030
Organisme : National Natural Science Foundation of China
ID : 8217131836
Organisme : Natural Science Foundation of the Higher Education Institutions of Jiangsu Province
ID : 18KJB360001
Organisme : Natural Science Foundation of Jiangsu Province
ID : Natural Science Foundation of Jiangsu Province
Organisme : Postdoctoral Research Fund of Jiangsu Province in 2021 category A
ID : 2021K010A

Informations de copyright

© 2023. The Author(s), under exclusive licence to American Association of Pharmaceutical Scientists.

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Auteurs

Xia Cao (X)

Department of Pharmaceutics, School of Pharmacy, Centre for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, People's Republic of China.
Medicinal Function Development of New Food Resources, Jiangsu Provincial Research Center, Zhenjiang, Jiangsu, People's Republic of China.
School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shanxi, 710072, People's Republic of China.

Qi Liu (Q)

Department of Pharmaceutics, School of Pharmacy, Centre for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, People's Republic of China.
Medicinal Function Development of New Food Resources, Jiangsu Provincial Research Center, Zhenjiang, Jiangsu, People's Republic of China.
School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shanxi, 710072, People's Republic of China.

Michael Adu-Frimpong (M)

Department of Pharmaceutics, School of Pharmacy, Centre for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, People's Republic of China.
Medicinal Function Development of New Food Resources, Jiangsu Provincial Research Center, Zhenjiang, Jiangsu, People's Republic of China.
School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shanxi, 710072, People's Republic of China.
Department of Biochemistry and Forensic Sciences, School of Chemical and Biochemical Sciences, C. K. Tedam University of Technology and Applied Sciences (CKT-UTAS), Navrongo, UK-0215-5321, Ghana.

Wenwan Shi (W)

Department of Pharmaceutics, School of Pharmacy, Centre for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, People's Republic of China.
Medicinal Function Development of New Food Resources, Jiangsu Provincial Research Center, Zhenjiang, Jiangsu, People's Republic of China.
School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shanxi, 710072, People's Republic of China.

Kai Liu (K)

Department of Pharmaceutics, School of Pharmacy, Centre for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, People's Republic of China.
Medicinal Function Development of New Food Resources, Jiangsu Provincial Research Center, Zhenjiang, Jiangsu, People's Republic of China.
School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shanxi, 710072, People's Republic of China.

Tianwen Deng (T)

Department of Pharmaceutics, School of Pharmacy, Centre for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, People's Republic of China.
Medicinal Function Development of New Food Resources, Jiangsu Provincial Research Center, Zhenjiang, Jiangsu, People's Republic of China.
School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shanxi, 710072, People's Republic of China.

Hui Yuan (H)

Department of Pharmaceutics, School of Pharmacy, Centre for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, People's Republic of China.
School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shanxi, 710072, People's Republic of China.

Xuedi Weng (X)

Department of Pharmaceutics, School of Pharmacy, Centre for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, People's Republic of China.
School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shanxi, 710072, People's Republic of China.

Yihong Gao (Y)

Department of Pharmaceutics, School of Pharmacy, Centre for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, People's Republic of China.
School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shanxi, 710072, People's Republic of China.

Qingtong Yu (Q)

Department of Pharmaceutics, School of Pharmacy, Centre for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, People's Republic of China.
Medicinal Function Development of New Food Resources, Jiangsu Provincial Research Center, Zhenjiang, Jiangsu, People's Republic of China.
School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shanxi, 710072, People's Republic of China.

Wenwen Deng (W)

Department of Pharmaceutics, School of Pharmacy, Centre for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, People's Republic of China.
Medicinal Function Development of New Food Resources, Jiangsu Provincial Research Center, Zhenjiang, Jiangsu, People's Republic of China.
School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shanxi, 710072, People's Republic of China.

Jiangnan Yu (J)

Department of Pharmaceutics, School of Pharmacy, Centre for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, People's Republic of China.
Medicinal Function Development of New Food Resources, Jiangsu Provincial Research Center, Zhenjiang, Jiangsu, People's Republic of China.
School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shanxi, 710072, People's Republic of China.

Qilong Wang (Q)

Department of Pharmaceutics, School of Pharmacy, Centre for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, People's Republic of China. 294353201@qq.com.
Medicinal Function Development of New Food Resources, Jiangsu Provincial Research Center, Zhenjiang, Jiangsu, People's Republic of China. 294353201@qq.com.
School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shanxi, 710072, People's Republic of China. 294353201@qq.com.

Gao Xiao (G)

School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shanxi, 710072, People's Republic of China. xgscu007@gmail.com.
College of Environment and Safety Engineering, Fuzhou University, Fuzhou, 350108, Fujian, People's Republic of China. xgscu007@gmail.com.

Ximing Xu (X)

Department of Pharmaceutics, School of Pharmacy, Centre for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, People's Republic of China. xmxu@ujs.edu.cn.
Medicinal Function Development of New Food Resources, Jiangsu Provincial Research Center, Zhenjiang, Jiangsu, People's Republic of China. xmxu@ujs.edu.cn.
School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shanxi, 710072, People's Republic of China. xmxu@ujs.edu.cn.

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