Lung proteome and metabolome endotype in HIV-associated obstructive lung disease.
Journal
ERJ open research
ISSN: 2312-0541
Titre abrégé: ERJ Open Res
Pays: England
ID NLM: 101671641
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
received:
12
07
2022
accepted:
24
11
2022
entrez:
23
3
2023
pubmed:
24
3
2023
medline:
24
3
2023
Statut:
epublish
Résumé
Obstructive lung disease is increasingly common among persons with HIV, both smokers and nonsmokers. We used aptamer proteomics to identify proteins and associated pathways in HIV-associated obstructive lung disease. Bronchoalveolar lavage fluid (BALF) samples from 26 persons living with HIV with obstructive lung disease were matched to persons living with HIV without obstructive lung disease based on age, smoking status and antiretroviral treatment. 6414 proteins were measured using SomaScan® aptamer-based assay. We used sparse distance-weighted discrimination (sDWD) to test for a difference in protein expression and permutation tests to identify univariate associations between proteins and forced expiratory volume in 1 s % predicted (FEV After filtering, we retained 3872 proteins for further analysis. Based on sDWD, protein expression was able to separate cases and controls. We found 575 proteins that were significantly correlated with FEV Protein expression differs in persons living with HIV with and without obstructive lung disease. We were not able to identify specific pathways differentially expressed among patients based on FEV
Identifiants
pubmed: 36949960
doi: 10.1183/23120541.00332-2022
pii: 00332-2022
pmc: PMC10026002
pii:
doi:
Types de publication
Journal Article
Langues
eng
Informations de copyright
Copyright ©The authors 2023.
Déclaration de conflit d'intérêts
Provenance: Submitted article, peer reviewed. Conflict of interest: No conflict of interest related to the work in this manuscript for any of the authors. K.M. Kunisaki reports consulting (Allergan/AbbVie), and independent data safety and monitoring boards (Nuvaira and Organicell), outside of this work.
Références
PLoS One. 2021 Apr 2;16(4):e0247493
pubmed: 33798209
Mucosal Immunol. 2020 Jul;13(4):637-651
pubmed: 32034274
Respir Med. 2011 Nov;105(11):1655-61
pubmed: 21703841
AIDS Res Ther. 2010 Mar 19;7:6
pubmed: 20298614
Qual Life Res. 2010 Nov;19(9):1295-302
pubmed: 20617387
Microbiome. 2016 Jan 20;4:3
pubmed: 26792212
Respirology. 2021 Apr;26(4):298-321
pubmed: 33506971
Clin Epigenetics. 2017 Apr 24;9:42
pubmed: 28450970
J Biol Chem. 2000 Jan 14;275(2):1233-40
pubmed: 10625668
Cell Death Dis. 2010 Nov 11;1:e99
pubmed: 21368875
Chest. 2021 Jun;159(6):2244-2253
pubmed: 33434499
Methods Mol Biol. 2019;2044:221-231
pubmed: 31432415
Ann Intern Med. 2000 Mar 7;132(5):369-72
pubmed: 10691587
Am J Respir Crit Care Med. 2001 Mar;163(3 Pt 1):737-44
pubmed: 11254533
Respir Res. 2011 Sep 01;12:117
pubmed: 21884608
Clin Physiol Funct Imaging. 2012 Jul;32(4):288-95
pubmed: 22681606
BMC Pulm Med. 2010 May 11;10:27
pubmed: 20459792
AIDS. 2016 Jun 1;30(9):1327-39
pubmed: 26990629
Chest. 2006 Nov;130(5):1326-33
pubmed: 17099007
J Acquir Immune Defic Syndr. 2020 Feb 1;83(2):189-196
pubmed: 31929407
J Clin Invest. 2009 Oct;119(10):2914-24
pubmed: 19759516
AIDS. 2014 Nov 13;28(17):2505-15
pubmed: 25574956
Am J Respir Crit Care Med. 2010 Sep 15;182(6):790-6
pubmed: 20522793
J Cachexia Sarcopenia Muscle. 2021 Dec;12(6):1803-1817
pubmed: 34523824
PLoS One. 2009 Jul 21;4(7):e6328
pubmed: 19621086
Eur J Clin Invest. 1999 Nov;29(11):964-72
pubmed: 10583442
Behav Brain Res. 2001 Nov 1;125(1-2):279-84
pubmed: 11682119
Am J Respir Crit Care Med. 2011 Feb 1;183(3):388-95
pubmed: 20851926
Eur Respir J. 2008 Feb;31(2):287-97
pubmed: 17989120
Pulm Pharmacol Ther. 2003;16(2):67-78
pubmed: 12670776
Bioinformatics. 2011 Oct 15;27(20):2917-8
pubmed: 21893519
Respir Res. 2006 Mar 30;7:53
pubmed: 16571143
AIDS. 2021 Jun 1;35(7):1031-1040
pubmed: 33635847
AIDS. 2013 May 15;27(8):1303-11
pubmed: 23299176
J Acquir Immune Defic Syndr. 2018 Aug 15;78(5):543-548
pubmed: 29683991
AIDS. 2019 Mar 15;33(4):655-664
pubmed: 30601153
Nucleic Acids Res. 2021 Jan 8;49(D1):D480-D489
pubmed: 33237286
J Infect Dis. 2022 Mar 2;225(5):862-867
pubmed: 34610114
Eur Respir J. 2012 Dec;40(6):1324-43
pubmed: 22743675
BMJ Open Respir Res. 2017 Apr 03;4(1):e000180
pubmed: 28409005
J Acquir Immune Defic Syndr. 2015 Nov 1;70(3):280-8
pubmed: 26181820
Am J Physiol Lung Cell Mol Physiol. 2014 Jan 1;306(1):L35-42
pubmed: 24213920
Infection. 2013 Apr;41(2):347-53
pubmed: 22971938