Investigation of a mpox outbreak in Central African Republic, 2021-2022.
Central African Republic
Emerging infectious diseases
Monkeypox virus
Outbreak investigation
Surveillance
Zoonosis
mpox
Journal
One health (Amsterdam, Netherlands)
ISSN: 2352-7714
Titre abrégé: One Health
Pays: Netherlands
ID NLM: 101660501
Informations de publication
Date de publication:
Jun 2023
Jun 2023
Historique:
received:
02
11
2022
revised:
01
03
2023
accepted:
02
03
2023
entrez:
23
3
2023
pubmed:
24
3
2023
medline:
24
3
2023
Statut:
ppublish
Résumé
Human monkeypox virus is spreading globally, and more information is required about its epidemiological and clinical disease characteristics in endemic countries. We report the investigation of an outbreak in November 2021 in Central African Republic (CAR). The primary case, a hunter, fell ill after contact with a non-human primate at the frontier between forest and savannah. The ensuing investigation in a small nearby town concerned two families and four waves of inter-human transmission, with 14 confirmed cases, 11 suspected cases and 17 non-infected contacts, and a secondary attack rate of 59.5% (25/42). Complications were observed in 12 of the 19 (63.2%) confirmed and suspected cases with available clinical follow-up data: eight cases of bronchopneumonia, two of severe dehydration, one corneal ulcer, one abscess, two cutaneous superinfections, and six cutaneous sequelae (cheloid scars, or depigmentation). There was one death, giving a case fatality ratio of 1/25 (4.0%) for confirmed and suspected cases. This outbreak, with the largest number of confirmed cases ever described in CAR, confirms the potential severity of the disease associated with clade I monkeypox viruses, and highlights the need for rapid control over virus circulation to prevent the further national and international spread of infection.
Identifiants
pubmed: 36950196
doi: 10.1016/j.onehlt.2023.100523
pii: S2352-7714(23)00043-5
pmc: PMC9988319
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100523Informations de copyright
© 2023 The Authors.
Déclaration de conflit d'intérêts
No conflicts of interest to declare.
Références
Emerg Infect Dis. 2007 Sep;13(9):1332-9
pubmed: 18252104
Emerg Infect Dis. 2021 Apr;27(4):
pubmed: 33756100
Semin Pediatr Infect Dis. 2004 Oct;15(4):280-7
pubmed: 15494953
Nat Microbiol. 2020 Jul;5(7):955-965
pubmed: 32341480
Emerg Infect Dis. 2022 Dec;28(12):2435-2445
pubmed: 36328951
Int J Infect Dis. 2022 Sep;122:107-111
pubmed: 35640830
J Med Virol. 2023 Jan;95(1):e27931
pubmed: 35692117
Elife. 2014 Sep 08;3:e04395
pubmed: 25201877
Lancet Infect Dis. 2004 Jan;4(1):15-25
pubmed: 14720564
Emerg Infect Dis. 2019 Aug;25(8):1602-1604
pubmed: 31216261
Emerg Infect Dis. 2016 Jun;22(6):1014-21
pubmed: 27191380
Lancet Infect Dis. 2022 Aug;22(8):1153-1162
pubmed: 35623380
PLoS One. 2017 Feb 13;12(2):e0168664
pubmed: 28192435
Lancet Infect Dis. 2019 Aug;19(8):872-879
pubmed: 31285143
Am J Trop Med Hyg. 2005 Aug;73(2):428-34
pubmed: 16103616
Clin Infect Dis. 2014 Jan;58(2):260-7
pubmed: 24158414
Int J STD AIDS. 2022 Sep;33(10):928-932
pubmed: 35969500
Pan Afr Med J. 2015 Sep 10;22:23
pubmed: 26664524
Trop Geogr Med. 1987 Apr;39(2):115-22
pubmed: 2820094
PLoS Negl Trop Dis. 2019 Oct 16;13(10):e0007791
pubmed: 31618206
Clin Microbiol Infect. 2016 Aug;22(8):658-9
pubmed: 27404372
Emerg Infect Dis. 2014 Jun;20(6):1009-11
pubmed: 24857667
PLoS Negl Trop Dis. 2022 Feb 11;16(2):e0010141
pubmed: 35148313
J Virol Methods. 2010 Oct;169(1):223-7
pubmed: 20643162
Infect Dis Now. 2022 Aug;52(5):294-298
pubmed: 35753629
Open Forum Infect Dis. 2017 Nov 03;4(4):ofx168
pubmed: 29732376
Bull World Health Organ. 1972;46(5):593-7
pubmed: 4340218
Ecohealth. 2020 Mar;17(1):64-73
pubmed: 31875271
Bull Soc Pathol Exot. 2016 Dec;109(5):358-363
pubmed: 27783372
Lancet Infect Dis. 2022 Sep;22(9):1321-1328
pubmed: 35785793
MMWR Morb Mortal Wkly Rep. 2018 Mar 16;67(10):306-310
pubmed: 29543790
Lancet. 2019 Mar 2;393(10174):936-948
pubmed: 30777297
Am J Trop Med Hyg. 2015 Aug;93(2):410-5
pubmed: 26013374
Sci Rep. 2021 Jun 22;11(1):13085
pubmed: 34158533
Environ Microbiol. 2022 Oct;24(10):4561-4569
pubmed: 35837859
Euro Surveill. 2022 Jun;27(22):
pubmed: 35656836
Ther Adv Infect Dis. 2022 Aug 26;9:20499361221124027
pubmed: 36051570
J Gen Virol. 2005 Oct;86(Pt 10):2661-2672
pubmed: 16186219
J Infect Dis. 2022 Apr 19;225(8):1367-1376
pubmed: 32880628
Emerg Infect Dis. 2010 Oct;16(10):1539-45
pubmed: 20875278
PLoS One. 2019 Apr 17;14(4):e0214229
pubmed: 30995249
Med Mal Infect. 2018 Jun;48(4):263-268
pubmed: 29573840
Euro Surveill. 2022 Jun;27(22):
pubmed: 35656834
Lancet. 2011 Oct 8;378(9799):1354
pubmed: 21982097
Bull World Health Organ. 1988;66(4):465-70
pubmed: 2844429