High Levels of C-Reactive Protein with Low Levels of Pentraxin 3 as Biomarkers for Central Serous Chorioretinopathy.
AMD, age-related macular degeneration
C-reactive protein
CRP, C-reactive protein
CSCR, central serous chorioretinopathy
Central serous chorioretinopathy
FH, factor H
Glucocorticoid
HPA, hypothalamic-pituitary-adrenal
IL, interleukin
Inflammation, Pentraxin 3
PTX, pentraxin
Journal
Ophthalmology science
ISSN: 2666-9145
Titre abrégé: Ophthalmol Sci
Pays: Netherlands
ID NLM: 9918230896206676
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
19
10
2022
revised:
26
01
2023
accepted:
27
01
2023
entrez:
23
3
2023
pubmed:
24
3
2023
medline:
24
3
2023
Statut:
epublish
Résumé
To investigate the association between the 2 acute phase proteins, C-reactive protein (CRP) and pentraxin 3 (PTX3) with central serous chorioretinopathy (CSCR), as PTX3 is a glucocorticoid-induced protein. Cross-sectional multicenter study. Patients with CSCR compared with age- and sex-matched healthy participants. Patients with CSCR from 3 centers in Europe were included in the study. The clinical form of CSCR was recorded. Blood samples from patients with CSCR and healthy participants were sampled, and high-sensitivity CRP and PTX3 levels were measured in the serum. C-reactive protein and PTX3 serum level comparison between patients with CSCR with age- and sex-matched healthy participants. Although CRP levels were higher in patients with CSCR (n = 216) than in age- and sex-matched controls (n = 130) (2.2 ± 3.2 mg/l vs. 1.5 mg/l ± 1.4, respectively, In patients with CSCR, high CRP and low PTX3 levels suggest a form of low-grade systemic inflammation together with a lack of glucocorticoid pathway activation, raising new hypotheses on the pathophysiology of CSCR. The author(s) have no proprietary or commercial interest in any materials discussed in this article.
Identifiants
pubmed: 36950301
doi: 10.1016/j.xops.2023.100278
pii: S2666-9145(23)00010-6
pmc: PMC10025279
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100278Informations de copyright
© 2023 Published by Elsevier Inc. on behalf of American Academy of Ophthalmology.
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