What is circulating factor disease and how is it currently explained?
Circulating factor disease
Nephrotic syndrome
Steroid sensitive nephrotic syndrome
Steroid-resistant nephrotic syndrome
Transplant recurrence
Journal
Pediatric nephrology (Berlin, Germany)
ISSN: 1432-198X
Titre abrégé: Pediatr Nephrol
Pays: Germany
ID NLM: 8708728
Informations de publication
Date de publication:
11 2023
11 2023
Historique:
received:
13
01
2023
accepted:
20
02
2023
revised:
15
02
2023
medline:
22
9
2023
pubmed:
24
3
2023
entrez:
23
3
2023
Statut:
ppublish
Résumé
Nephrotic syndrome (NS) consists of the clinical triad of hypoalbuminaemia, high levels of proteinuria and oedema, and describes a heterogeneous group of disease processes with different underlying drivers. The existence of circulating factor disease (CFD) as a driver of NS has been epitomised by a subset of patients who exhibit disease recurrence after transplantation, alongside laboratory work. Several circulating factors have been proposed and studied, broadly grouped into protease components such as soluble urokinase-type plasminogen activator (suPAR), hemopexin (Hx) and calcium/calmodulin-serine protease kinase (CASK), and other circulating proteases, and immune components such as TNF-α, CD40 and cardiotrophin-like cytokine-1 (CLC-1). While currently there is no definitive way of assessing risk of CFD pre-transplantation, promising work is emerging through the study of 'multi-omic' bioinformatic data from large national cohorts and biobanks.
Identifiants
pubmed: 36952039
doi: 10.1007/s00467-023-05928-8
pii: 10.1007/s00467-023-05928-8
pmc: PMC10514121
doi:
Substances chimiques
Receptors, Urokinase Plasminogen Activator
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3513-3518Subventions
Organisme : Medical Research Council
ID : MR/W000105/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R003017/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P024297/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R013942/1
Pays : United Kingdom
Informations de copyright
© 2023. The Author(s).
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