IL-6/gp130 signaling: a key unlocking regeneration.

Journal

Cell regeneration (London, England)
ISSN: 2045-9769
Titre abrégé: Cell Regen
Pays: China
ID NLM: 101627311

Informations de publication

Date de publication:
23 Mar 2023
Historique:
entrez: 23 3 2023
pubmed: 24 3 2023
medline: 24 3 2023
Statut: epublish

Résumé

Liver is an organ with notable capacity of regeneration. Reprogramming of hepatocytes towards an immature state is one of the important mechanisms for hepatocyte replenishment. Inflammatory response mediated by IL-6 and its family cytokines has been widely reported closely related with tissue regeneration in myriads of organs. Recently Hui and colleagues reported that the dedifferentiation of hepatocytes depends upon IL-6 signaling from Kupffer cells and the reprogramming of gene expression under the inflammatory condition is different from the regulation of gene expression during embryo hepatocyte specification, highlighting a tight linkage between extracellular microenvironment and parenchymal cell plasticity during tissue regenerative repair.

Identifiants

DOI: 10.1186/s13619-023-00160-z PMID: 36952066 PMC: PMC10036683
pubmed: 36952066
doi: 10.1186/s13619-023-00160-z
pii: 10.1186/s13619-023-00160-z
pmc: PMC10036683
doi:

Types de publication

Journal Article

Langues

eng

Pagination

16

Informations de copyright

© 2023. The Author(s).

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Auteurs

Ruopu Li (R)

State Key Laboratory of Cardiovascular Disease, Fuwai Hospital & Cardiovascular Institute, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Street, Beilishi Road, Xicheng District, 100037, Beijing, People's Republic of China.

Deqiang Li (D)

The Center for Cardiovascular Research, the Research Institute at Nationwide Children's Hospital, 575 Children's Drive, Columbus, OH, 43215, USA.
The Department of Pediatrics, College of Medicine, Ohio State University, Columbus, OH, 43215, USA.

Yu Nie (Y)

State Key Laboratory of Cardiovascular Disease, Fuwai Hospital & Cardiovascular Institute, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Street, Beilishi Road, Xicheng District, 100037, Beijing, People's Republic of China. nieyu@fuwaihospital.org.
National Health Commission Key Laboratory of Cardiovascular Regenerative Medicine, Fuwai Central-China Hospital, Central China Branch of National Center for Cardiovascular Diseases, 450046, Zhengzhou, China. nieyu@fuwaihospital.org.
Shenzhen Key Laboratory of Cardiovascular Disease, Fuwai Hospital Chinese Academy of Medical Sciences, 518057, Shenzhen, China. nieyu@fuwaihospital.org.

Classifications MeSH