A survey of open questions in adaptive therapy: Bridging mathematics and clinical translation.
adaptive therapy
cancer biology
cancer evolution & evolution
drug resistance
mathematical modeling
medicine
predictive modeling
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
23 03 2023
23 03 2023
Historique:
received:
18
10
2022
accepted:
27
02
2023
entrez:
23
3
2023
pubmed:
24
3
2023
medline:
28
3
2023
Statut:
epublish
Résumé
Adaptive therapy is a dynamic cancer treatment protocol that updates (or 'adapts') treatment decisions in anticipation of evolving tumor dynamics. This broad term encompasses many possible dynamic treatment protocols of patient-specific dose modulation or dose timing. Adaptive therapy maintains high levels of tumor burden to benefit from the competitive suppression of treatment-sensitive subpopulations on treatment-resistant subpopulations. This evolution-based approach to cancer treatment has been integrated into several ongoing or planned clinical trials, including treatment of metastatic castrate resistant prostate cancer, ovarian cancer, and BRAF-mutant melanoma. In the previous few decades, experimental and clinical investigation of adaptive therapy has progressed synergistically with mathematical and computational modeling. In this work, we discuss 11 open questions in cancer adaptive therapy mathematical modeling. The questions are split into three sections: (1) integrating the appropriate components into mathematical models (2) design and validation of dosing protocols, and (3) challenges and opportunities in clinical translation.
Identifiants
pubmed: 36952376
doi: 10.7554/eLife.84263
pii: 84263
pmc: PMC10036119
doi:
pii:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : U01CA232382
Pays : United States
Organisme : NCI NIH HHS
ID : U54CA193489
Pays : United States
Informations de copyright
© 2023, West et al.
Déclaration de conflit d'intérêts
JW, FA, JG, MS, RB, JB, MR, EK, RN, YV, DB, AA No competing interests declared
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