A polygenic and family risk score are both independently associated with risk of type 2 diabetes in a population-based study.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
23 03 2023
23 03 2023
Historique:
received:
27
10
2022
accepted:
13
03
2023
entrez:
24
3
2023
pubmed:
25
3
2023
medline:
28
3
2023
Statut:
epublish
Résumé
The availability of polygenic scores for type 2 diabetes (T2D) raises the question, whether assessing family history might become redundant. However, family history not only involves shared genetics, but also shared environment. It was the aim of this study to assess the independent and combined effects of one family risk score (FamRS) and a polygenic score (PGS) on prevalent and incident T2D risk in a population-based study from Germany (n = 3071). The study was conducted in 2004/2005 with up to 12 years of follow-up. The FamRS takes into account not only the number of diseased first grade relatives, but also age at onset of the relatives and age of participants. 256 prevalent and additional 163 incident T2D cases were recorded. Prevalence of T2D increased sharply for those within the top quantile of the PGS distribution resulting in an OR of 19.16 (p < 2 × 10
Identifiants
pubmed: 36959271
doi: 10.1038/s41598-023-31496-w
pii: 10.1038/s41598-023-31496-w
pmc: PMC10036612
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4805Informations de copyright
© 2023. The Author(s).
Références
Diabetes. 2000 Dec;49(12):2201-7
pubmed: 11118026
Nat Genet. 2016 Oct;48(10):1279-83
pubmed: 27548312
Endocr Rev. 2019 Dec 1;40(6):1500-1520
pubmed: 31322649
Annu Rev Genomics Hum Genet. 2003;4:257-91
pubmed: 14527304
Hum Genet. 2015 Feb;134(2):259-67
pubmed: 25543539
Nat Genet. 2018 Nov;50(11):1505-1513
pubmed: 30297969
Atherosclerosis. 2022 Jul;352:10-17
pubmed: 35636145
Diabetes Metab Res Rev. 2020 Feb;36(2):e3214
pubmed: 31465628
Genet Med. 2006 Feb;8(2):102-8
pubmed: 16481893
Diabetologia. 2011 Nov;54(11):2811-9
pubmed: 21826484
Am J Cardiol. 2001 Jan 15;87(2):129-35
pubmed: 11152826
Nat Genet. 2021 Apr;53(4):420-425
pubmed: 33692568
Gesundheitswesen. 2005 Aug;67 Suppl 1:S19-25
pubmed: 16032513
J Pers Med. 2020 Dec 22;11(1):
pubmed: 33375163
Stat Med. 2009 Apr 15;28(8):1269-83
pubmed: 19170247
Twin Res Hum Genet. 2015 Dec;18(6):762-71
pubmed: 26678054
Nat Genet. 2016 Oct;48(10):1284-1287
pubmed: 27571263
Cell Genom. 2022 Jul 13;2(7):
pubmed: 35935918
Genet Epidemiol. 1999;17(2):141-50
pubmed: 10414557
Diabetologia. 1999 Feb;42(2):139-45
pubmed: 10064092
J Intern Med. 2011 Oct;270(4):388-96
pubmed: 21251094
Atherosclerosis. 2014 Nov;237(1):243-50
pubmed: 25259422
Gesundheitswesen. 2005 Aug;67 Suppl 1:S13-8
pubmed: 16032512
Diabetologia. 2013 Jan;56(1):60-9
pubmed: 23052052
Cell Genom. 2022 Apr 13;2(4):None
pubmed: 35591975
Nat Genet. 2013 Apr;45(4):400-5, 405e1-3
pubmed: 23455638
Diabetol Metab Syndr. 2016 Nov 9;8:71
pubmed: 27833664
Diabetologia. 2020 Jul;63(7):1324-1332
pubmed: 32291466
Stroke. 2022 Jul;53(7):2331-2339
pubmed: 35387493
Nature. 2015 Oct 1;526(7571):68-74
pubmed: 26432245
Diabetologia. 2022 Nov;65(11):1796-1803
pubmed: 35916901
Eur Heart J. 2016 Feb 7;37(6):561-7
pubmed: 26392438
Circ Genom Precis Med. 2021 Feb;14(1):e003128
pubmed: 33433237
Nat Genet. 2018 Sep;50(9):1219-1224
pubmed: 30104762
Am J Epidemiol. 2020 May 5;189(5):445-460
pubmed: 31647510
Diabetes Metab Syndr. 2019 Jul - Aug;13(4):2503-2506
pubmed: 31405668