Neurons in human pre-supplementary motor area encode key computations for value-based choice.
Journal
Nature human behaviour
ISSN: 2397-3374
Titre abrégé: Nat Hum Behav
Pays: England
ID NLM: 101697750
Informations de publication
Date de publication:
Jun 2023
Jun 2023
Historique:
received:
17
12
2021
accepted:
02
02
2023
medline:
26
6
2023
pubmed:
25
3
2023
entrez:
24
3
2023
Statut:
ppublish
Résumé
Adaptive behaviour in real-world environments requires that choices integrate several variables, including the novelty of the options under consideration, their expected value and uncertainty in value estimation. Here, to probe how integration over decision variables occurs during decision-making, we recorded neurons from the human pre-supplementary motor area (preSMA), ventromedial prefrontal cortex and dorsal anterior cingulate. Unlike the other areas, preSMA neurons not only represented separate pre-decision variables for each choice option but also encoded an integrated utility signal for each choice option and, subsequently, the decision itself. Post-decision encoding of variables for the chosen option was more widely distributed and especially prominent in the ventromedial prefrontal cortex. Our findings position the human preSMA as central to the implementation of value-based decisions.
Identifiants
pubmed: 36959327
doi: 10.1038/s41562-023-01548-2
pii: 10.1038/s41562-023-01548-2
pmc: PMC10330469
mid: NIHMS1902916
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
970-985Subventions
Organisme : NIMH NIH HHS
ID : P50 MH094258
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA040011
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH111425
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH110831
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS117839
Pays : United States
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature Limited.
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