Co-option of epidermal cells enables touch sensing.
Journal
Nature cell biology
ISSN: 1476-4679
Titre abrégé: Nat Cell Biol
Pays: England
ID NLM: 100890575
Informations de publication
Date de publication:
04 2023
04 2023
Historique:
received:
18
03
2022
accepted:
20
02
2023
medline:
18
4
2023
pubmed:
25
3
2023
entrez:
24
3
2023
Statut:
ppublish
Résumé
The epidermis is equipped with specialized mechanosensory organs that enable the detection of tactile stimuli. Here, by examining the differentiation of the tactile bristles, mechanosensory organs decorating the Drosophila adult epidermis, we show that neighbouring epidermal cells are essential for touch perception. Each mechanosensory bristle signals to the surrounding epidermis to co-opt a single epidermal cell, which we named the F-Cell. Once specified, the F-Cell adopts a specialized morphology to ensheath each bristle. Functional assays reveal that adult mechanosensory bristles require association with the epidermal F-Cell for touch sensing. Our findings underscore the importance of resident epidermal cells in the assembly of functional touch-sensitive organs.
Identifiants
pubmed: 36959505
doi: 10.1038/s41556-023-01110-2
pii: 10.1038/s41556-023-01110-2
pmc: PMC10104782
mid: EMS170579
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
540-549Subventions
Organisme : Wellcome Trust
ID : 209412
Pays : United Kingdom
Organisme : Wellcome Trust
ID : FC001317
Pays : United Kingdom
Organisme : Arthritis Research UK
ID : FC001317
Pays : United Kingdom
Organisme : Medical Research Council
ID : FC001175
Pays : United Kingdom
Organisme : Cancer Research UK
ID : FC001317
Pays : United Kingdom
Organisme : Medical Research Council
ID : CC2138
Pays : United Kingdom
Organisme : Wellcome Trust
ID : CC2138
Pays : United Kingdom
Organisme : Wellcome Trust
ID : FC001175
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 107885
Pays : United Kingdom
Organisme : Cancer Research UK
ID : CC2138
Pays : United Kingdom
Organisme : Arthritis Research UK
ID : FC001175
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Cancer Research UK
ID : FC001175
Pays : United Kingdom
Commentaires et corrections
Type : CommentIn
Type : ErratumIn
Informations de copyright
© 2023. The Author(s).
Références
Methods. 2014 Jun 15;68(1):151-9
pubmed: 24530508
Curr Biol. 2016 Oct 24;26(20):R1022-R1038
pubmed: 27780045
Development. 1994 Jun;120(6):1433-41
pubmed: 8050354
Nat Cell Biol. 2001 Jan;3(1):50-7
pubmed: 11146626
Neuron. 1994 Jun;12(6):1195-206
pubmed: 8011334
Science. 2000 Mar 24;287(5461):2229-34
pubmed: 10744543
Cell Rep. 2018 Dec 4;25(10):2836-2850.e4
pubmed: 30517870
Trends Neurosci. 2021 Apr;44(4):323-335
pubmed: 33257000
J Cell Biol. 2010 Oct 18;191(2):237-48
pubmed: 20956378
Proc Natl Acad Sci U S A. 2009 May 19;106(20):8284-9
pubmed: 19429710
Cell Rep. 2012 Oct 25;2(4):991-1001
pubmed: 23063364
Cell. 1994 Feb 11;76(3):415-8
pubmed: 8313463
Neural Dev. 2008 Apr 30;3:12
pubmed: 18668998
Nat Neurosci. 2006 May;9(5):703-9
pubmed: 16582903
Pflugers Arch. 2007 Aug;454(5):703-20
pubmed: 17436012
Nat Rev Neurosci. 2021 Sep;22(9):521-537
pubmed: 34312536
EMBO J. 1994 Apr 1;13(7):1628-35
pubmed: 8157002
Mol Cell. 1999 Dec;4(6):883-91
pubmed: 10635314
Nature. 1980 Jul 3;286(5768):65-7
pubmed: 7393324
EMBO J. 1991 Oct;10(10):2975-83
pubmed: 1717258
J Embryol Exp Morphol. 1981 Dec;66:57-80
pubmed: 6802923
PLoS One. 2012;7(6):e38011
pubmed: 22723842
Front Cell Dev Biol. 2021 Aug 11;9:687732
pubmed: 34458255
Development. 2020 Aug 14;147(15):
pubmed: 32680934
Dev Biol. 1995 Dec;172(2):479-94
pubmed: 8612965
Development. 1996 Jan;122(1):223-30
pubmed: 8565833
Mol Cell Biol. 2014 Feb;34(4):664-72
pubmed: 24324007
Nat Methods. 2012 Jun 28;9(7):676-82
pubmed: 22743772
Science. 1995 Apr 14;268(5208):225-32
pubmed: 7716513
Development. 1989 Oct;107(2):389-405
pubmed: 2517255
Development. 1997 Jan;124(2):343-51
pubmed: 9053310
Methods Cell Biol. 2017;140:69-83
pubmed: 28528642
Mech Dev. 1994 Oct;48(1):25-33
pubmed: 7833286
Development. 1997 Feb;124(4):761-71
pubmed: 9043058
J Cell Biol. 2010 May 17;189(4):681-9
pubmed: 20457764
Dev Genet. 1996;18(1):28-39
pubmed: 8742832
J Comp Physiol A. 1987 Aug;161(2):329-33
pubmed: 2442382
Development. 2005 Aug;132(15):3333-44
pubmed: 15975935
Dev Cell. 2008 Mar;14(3):377-87
pubmed: 18258485
Dev Biol. 2004 May 1;269(1):1-17
pubmed: 15081353
Science. 2009 Jun 19;324(5934):1580-2
pubmed: 19541997
J Neurosci. 1990 Feb;10(2):491-9
pubmed: 2154560
Scan Electron Microsc. 1981;(Pt 2):73-6
pubmed: 7323733
Neuron. 2018 Oct 24;100(2):349-360
pubmed: 30359601
Dev Biol. 1985 Feb;107(2):420-31
pubmed: 3918895
Nat Rev Mol Cell Biol. 2009 Jan;10(1):44-52
pubmed: 19197331
J Neurosci. 2016 Nov 2;36(44):11275-11282
pubmed: 27807168
Trends Neurosci. 2001 May;24(5):251-4
pubmed: 11311363
Front Neural Circuits. 2022 Dec 16;16:917251
pubmed: 36589862
J Cell Sci. 2017 Jan 1;130(1):278-291
pubmed: 27445312
Development. 2003 Jan;130(1):123-33
pubmed: 12441297
Microsc Res Tech. 1997 Dec 15;39(6):506-31
pubmed: 9438251
Science. 2017 Nov 3;358(6363):615-623
pubmed: 29097543
BMC Bioinformatics. 2010 May 21;11:274
pubmed: 20492697
Development. 1993 Jun;118(2):401-15
pubmed: 8223268
Curr Biol. 2005 Oct 25;15(20):1847-54
pubmed: 16243032
Development. 2002 Apr;129(8):1975-82
pubmed: 11934863
PLoS Biol. 2004 Nov;2(11):e329
pubmed: 15514700
Cell. 2000 Dec 8;103(6):957-69
pubmed: 11136980
Development. 2005 May;132(10):2287-97
pubmed: 15829522
J Vis Exp. 2020 Jun 2;(160):
pubmed: 32568222
Genes Dev. 1992 Sep;6(9):1752-69
pubmed: 1516831
Science. 2014 Nov 21;346(6212):950-4
pubmed: 25414303
PLoS Genet. 2018 Jul 20;14(7):e1007528
pubmed: 30028887
Dev Biol. 2009 May 15;329(2):386-99
pubmed: 19232522
Development. 2017 Nov 15;144(22):4078-4090
pubmed: 29138290