Immunohistochemical Features of MMP-9 and pSTAT1 in Granuloma Annulare and Sarcoidosis: A Comparative Study of 62 Cases.


Journal

Journal of immunology research
ISSN: 2314-7156
Titre abrégé: J Immunol Res
Pays: Egypt
ID NLM: 101627166

Informations de publication

Date de publication:
2023
Historique:
received: 18 11 2022
revised: 14 02 2023
accepted: 16 02 2023
entrez: 24 3 2023
pubmed: 25 3 2023
medline: 28 3 2023
Statut: epublish

Résumé

Granuloma annulare (GA) and sarcoidosis are granulomatous inflammatory diseases that share similarities. To identify the histological and immunohistochemical (IHC) features of GA and sarcoidosis. A retrospective review of 36 patients with GA and 26 with sarcoidosis was performed. Results from hematoxylin and eosin (H&E) staining and IHC staining of MMP-9 and pSTAT1 within the skin lesions of GA and sarcoidosis were analyzed, and random forest was applied for developing a predictive model. Significantly greater expressions of MMP-9 (especially in elastic fibers, EFs, These results indicate that MMP-9 and pSTAT1 might exert roles in granulomatous inflammation in different modes, and the presence of more robust MMP-9 staining in EFs appears to be more suggestive of GA.

Sections du résumé

Background UNASSIGNED
Granuloma annulare (GA) and sarcoidosis are granulomatous inflammatory diseases that share similarities.
Objective UNASSIGNED
To identify the histological and immunohistochemical (IHC) features of GA and sarcoidosis.
Methods UNASSIGNED
A retrospective review of 36 patients with GA and 26 with sarcoidosis was performed. Results from hematoxylin and eosin (H&E) staining and IHC staining of MMP-9 and pSTAT1 within the skin lesions of GA and sarcoidosis were analyzed, and random forest was applied for developing a predictive model.
Results UNASSIGNED
Significantly greater expressions of MMP-9 (especially in elastic fibers, EFs,
Conclusion UNASSIGNED
These results indicate that MMP-9 and pSTAT1 might exert roles in granulomatous inflammation in different modes, and the presence of more robust MMP-9 staining in EFs appears to be more suggestive of GA.

Identifiants

pubmed: 36959923
doi: 10.1155/2023/4098459
pmc: PMC10030222
doi:

Substances chimiques

Matrix Metalloproteinase 9 EC 3.4.24.35

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

4098459

Informations de copyright

Copyright © 2023 Ze Wu et al.

Déclaration de conflit d'intérêts

The authors declare no conflicts of interest.

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Auteurs

Ze Wu (Z)

Department of Dermatology, General Hospital of Northern Theater Command, No. 83 Wenhua Road, Shenhe District, 110016 Shenyang, China.

Linghui Li (L)

Department of Dermatology, General Hospital of Northern Theater Command, No. 83 Wenhua Road, Shenhe District, 110016 Shenyang, China.

Hui Qu (H)

College of Medicine and Biological Information Engineering, Northeastern University, No. 3-11, Wenhua Road, Heping District, 110819 Shenyang, China.

Rui-Qun Qi (RQ)

Department of Dermatology, The First Hospital of China Medical University, No. 155 Nanjing Bei Street, Heping District, 110001 Shenyang, China.
Key Laboratory of Immunodermatology, Ministry of Education and NHC, National Joint Engineering Research Center for Theranostics of Immunological Skin Diseases, No. 155 Nanjing Bei Street, Heping District, 110001 Shenyang, China.

Jun Niu (J)

Department of Dermatology, General Hospital of Northern Theater Command, No. 83 Wenhua Road, Shenhe District, 110016 Shenyang, China.

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Classifications MeSH