Immunohistochemical Features of MMP-9 and pSTAT1 in Granuloma Annulare and Sarcoidosis: A Comparative Study of 62 Cases.
Journal
Journal of immunology research
ISSN: 2314-7156
Titre abrégé: J Immunol Res
Pays: Egypt
ID NLM: 101627166
Informations de publication
Date de publication:
2023
2023
Historique:
received:
18
11
2022
revised:
14
02
2023
accepted:
16
02
2023
entrez:
24
3
2023
pubmed:
25
3
2023
medline:
28
3
2023
Statut:
epublish
Résumé
Granuloma annulare (GA) and sarcoidosis are granulomatous inflammatory diseases that share similarities. To identify the histological and immunohistochemical (IHC) features of GA and sarcoidosis. A retrospective review of 36 patients with GA and 26 with sarcoidosis was performed. Results from hematoxylin and eosin (H&E) staining and IHC staining of MMP-9 and pSTAT1 within the skin lesions of GA and sarcoidosis were analyzed, and random forest was applied for developing a predictive model. Significantly greater expressions of MMP-9 (especially in elastic fibers, EFs, These results indicate that MMP-9 and pSTAT1 might exert roles in granulomatous inflammation in different modes, and the presence of more robust MMP-9 staining in EFs appears to be more suggestive of GA.
Sections du résumé
Background
UNASSIGNED
Granuloma annulare (GA) and sarcoidosis are granulomatous inflammatory diseases that share similarities.
Objective
UNASSIGNED
To identify the histological and immunohistochemical (IHC) features of GA and sarcoidosis.
Methods
UNASSIGNED
A retrospective review of 36 patients with GA and 26 with sarcoidosis was performed. Results from hematoxylin and eosin (H&E) staining and IHC staining of MMP-9 and pSTAT1 within the skin lesions of GA and sarcoidosis were analyzed, and random forest was applied for developing a predictive model.
Results
UNASSIGNED
Significantly greater expressions of MMP-9 (especially in elastic fibers, EFs,
Conclusion
UNASSIGNED
These results indicate that MMP-9 and pSTAT1 might exert roles in granulomatous inflammation in different modes, and the presence of more robust MMP-9 staining in EFs appears to be more suggestive of GA.
Identifiants
pubmed: 36959923
doi: 10.1155/2023/4098459
pmc: PMC10030222
doi:
Substances chimiques
Matrix Metalloproteinase 9
EC 3.4.24.35
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4098459Informations de copyright
Copyright © 2023 Ze Wu et al.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
Références
J Am Acad Dermatol. 2020 Mar;82(3):612-621
pubmed: 31185230
J Allergy Clin Immunol. 2015 Mar;135(3):626-35
pubmed: 25528359
J Cutan Pathol. 2019 Jul;46(7):471-478
pubmed: 30883851
Blood Adv. 2019 Sep 24;3(18):2751-2763
pubmed: 31540902
J Clin Invest. 2011 May;121(5):1686-8
pubmed: 21519148
J Dermatol. 2017 Mar;44(3):297-303
pubmed: 28256762
Int J Mol Sci. 2019 Oct 22;20(20):
pubmed: 31652545
J Am Acad Dermatol. 2012 May;66(5):699.e1-18; quiz 717-8
pubmed: 22507585
J Am Acad Dermatol. 2016 Sep;75(3):457-465
pubmed: 27543209
Arch Dermatol Res. 2000 Aug;292(8):384-90
pubmed: 10994772
J Eur Acad Dermatol Venereol. 2009 Jun;23(6):678-82
pubmed: 19298487
PLoS One. 2013 Nov 15;8(11):e80908
pubmed: 24260507
Nat Commun. 2021 May 12;12(1):2742
pubmed: 33980846
Am J Clin Dermatol. 2022 Jan;23(1):37-50
pubmed: 34495491
Clin Exp Dermatol. 2017 Dec;42(8):920-921
pubmed: 28929530
J Cutan Pathol. 2004 May;31(5):353-61
pubmed: 15059219
Aging (Albany NY). 2023 Jan 10;15(1):53-69
pubmed: 36629518
Oncoimmunology. 2022 Feb 1;11(1):2032918
pubmed: 35127254
J Eur Acad Dermatol Venereol. 2010 Jul;24(7):747-55
pubmed: 20015176
Sci Rep. 2017 Jun 26;7(1):4237
pubmed: 28652588
J Allergy Clin Immunol. 2021 May;147(5):1646-1647
pubmed: 33713770
Int Immunopharmacol. 2022 Jan;102:107188
pubmed: 34407915
Dermatol Ther. 2022 Jan;35(1):e15188
pubmed: 34730269
Infect Immun. 2006 Nov;74(11):6135-44
pubmed: 16982845
Am J Respir Cell Mol Biol. 2019 Aug;61(2):198-208
pubmed: 30741559
Am J Dermatopathol. 2015 Jul;37(7):547-50
pubmed: 25140662
Acta Derm Venereol. 2020 Jun 15;100(13):adv00182
pubmed: 32378725
Clin Immunol. 2009 Aug;132(2):174-83
pubmed: 19464956
Nat Rev Immunol. 2004 Aug;4(8):617-29
pubmed: 15286728
Science. 2010 Jan 22;327(5964):466-9
pubmed: 20007864
J Cancer. 2021 Feb 22;12(8):2243-2257
pubmed: 33758602
JAMA. 2011 Jan 26;305(4):391-9
pubmed: 21266686
Yale J Biol Med. 2020 Mar 27;93(1):187-195
pubmed: 32226347