Integrated Small Animal PET/CT/RT with Onboard PET/CT Image Guidance for Preclinical Radiation Oncology Research.
PET/CT/RT
onboard PET/CT image
preclinical radiotherapy research
small animal PET
Journal
Tomography (Ann Arbor, Mich.)
ISSN: 2379-139X
Titre abrégé: Tomography
Pays: Switzerland
ID NLM: 101671170
Informations de publication
Date de publication:
04 03 2023
04 03 2023
Historique:
received:
02
02
2023
revised:
22
02
2023
accepted:
02
03
2023
entrez:
24
3
2023
pubmed:
25
3
2023
medline:
28
3
2023
Statut:
epublish
Résumé
We have integrated a compact and lightweight PET with an existing CT image-guided small animal irradiator to enable practical onboard PET/CT image-guided preclinical radiation therapy (RT) research. The PET with a stationary and full-ring detectors has ~1.1 mm uniform spatial resolution over its imaging field-of-view of 8.0 cm diameter and 3.5 cm axial length and was mechanically installed inside the irradiator in a tandem configuration with CT and radiation unit. A common animal bed was used for acquiring sequential dual functional and anatomical images with independent PET and CT control and acquisition systems. The reconstructed dual images were co-registered based on standard multi-modality image calibration and registration processes. Phantom studies were conducted to evaluate the integrated system and dual imaging performance. The measured mean PET/CT image registration error was ~0.3 mm. With one-bed and three-bed acquisitions, initial tumor focused and whole-body [
Identifiants
pubmed: 36961005
pii: tomography9020046
doi: 10.3390/tomography9020046
pmc: PMC10037572
doi:
Substances chimiques
Fluorodeoxyglucose F18
0Z5B2CJX4D
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
567-578Subventions
Organisme : NIBIB NIH HHS
ID : R01 EB019438
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA218402
Pays : United States
Organisme : NIBIB NIH HHS
ID : R03 EB032476
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA196516
Pays : United States
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