Efficacy and safety of antiparasitic therapy for neurocysticercosis in rural Tanzania: a prospective cohort study.
Albendazole
Antiparasitic medication
Neglected tropical diseases
Neurocysticercosis
Praziquantel
Taenia solium
Journal
Infection
ISSN: 1439-0973
Titre abrégé: Infection
Pays: Germany
ID NLM: 0365307
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
received:
17
11
2022
accepted:
11
03
2023
medline:
19
7
2023
pubmed:
25
3
2023
entrez:
24
3
2023
Statut:
ppublish
Résumé
Neurocysticercosis is common in regions endemic for Taenia solium. Active-stage neurocysticercosis can be treated with antiparasitic medication, but so far no study on efficacy and safety has been conducted in Africa. We conducted a prospective cohort study on treatment of neurocysticercosis in Tanzania between August 2018 and January 2022. Patients were initially treated with albendazole (15 mg/kg/d) for 10 days and followed up for 6 months. Additionally in July 2021, all participants who then still had cysts were offered a combination therapy consisting of albendazole (15 mg/kg/d) and praziquantel (50 mg/kg/d). Antiparasitic treatment was accompanied by corticosteroid medication and anti-seizure medication if the patient had experienced epileptic seizures before treatment. Sixty-three patients were recruited for this study, of whom 17 had a complete follow-up after albendazole monotherapy. These patients had a total of 138 cysts at baseline, of which 58 (42%) had disappeared or calcified by the end of follow-up. The median cyst reduction was 40% (interquartile range 11-63%). Frequency of epileptic seizures reduced considerably (p < 0.001). Three patients had all active cysts resolved or calcified and of the remaining 14, eight received the combination therapy which resolved 63 of 66 cysts (95%). Adverse events were infrequent and mild to moderate during both treatment cycles. Cyst resolution was unsatisfactory with albendazole monotherapy but was very high when it was followed by a combination of albendazole and praziquantel.
Identifiants
pubmed: 36961623
doi: 10.1007/s15010-023-02021-y
pii: 10.1007/s15010-023-02021-y
pmc: PMC10037392
doi:
Substances chimiques
Albendazole
F4216019LN
Antiparasitic Agents
0
Praziquantel
6490C9U457
Anthelmintics
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1127-1139Subventions
Organisme : Bundesministerium für Bildung und Forschung
ID : 01KA1617
Organisme : European and Developing Countries Clinical Trials Partnership
ID : DRIA2014-308
Informations de copyright
© 2023. The Author(s).
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