Structural constraints link differences in neutralization potency of human anti-Eastern equine encephalitis virus monoclonal antibodies.

Humans Horses Animals Encephalitis Virus, Eastern Equine Antibodies, Neutralizing Antibodies, Viral Cryoelectron Microscopy Epitopes Encephalomyelitis, Equine Antibodies, Monoclonal Neutralization Tests
alphavirus antibodies, human monoclonal cryo-EM neutralization therapy

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
28 03 2023
Historique:
medline: 28 3 2023
entrez: 24 3 2023
pubmed: 25 3 2023
Statut: ppublish

Résumé

Selection and development of monoclonal antibody (mAb) therapeutics against pathogenic viruses depends on certain functional characteristics. Neutralization potency, or the half-maximal inhibitory concentration (IC

Identifiants

DOI: 10.1073/pnas.2213690120 PMID: 36961925 PMC: PMC10068833
pubmed: 36961925
doi: 10.1073/pnas.2213690120
pmc: PMC10068833
doi:

Substances chimiques

Antibodies, Neutralizing 0
Antibodies, Viral 0
Epitopes 0
Antibodies, Monoclonal 0

Types de publication

Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2213690120

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI095366
Pays : United States
Organisme : NIAID NIH HHS
ID : HHSN272201700041I
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL069765
Pays : United States
Organisme : NIAID NIH HHS
ID : F31 AI145189
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002243
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI142790
Pays : United States

Références

PLoS One. 2010 Jul 08;5(7):e11479
pubmed: 20628602
Methods Mol Biol. 2014;1117:401-43
pubmed: 24357374
Sci Immunol. 2019 Feb 22;4(32):
pubmed: 30796092
N Engl J Med. 2019 Nov 21;381(21):1989-1992
pubmed: 31747726
Cell Rep. 2020 Apr 28;31(4):107584
pubmed: 32348755
Nature. 2010 Dec 2;468(7324):705-8
pubmed: 21124457
J Infect Dis. 2004 Mar 15;189(6):1013-7
pubmed: 14999604
Viruses. 2019 Mar 22;11(3):
pubmed: 30909385
Science. 1967 Dec 8;158(3806):1283-6
pubmed: 6058003
Nat Methods. 2012 Sep;9(9):853-4
pubmed: 22842542
Elife. 2013 Apr 02;2:e00435
pubmed: 23577234
Structure. 2006 Jan;14(1):63-73
pubmed: 16407066
J Med Entomol. 2020 Sep 7;57(5):1627-1634
pubmed: 32280994
Antiviral Res. 2012 Jun;94(3):242-57
pubmed: 22522323
J Comput Chem. 2004 Oct;25(13):1605-12
pubmed: 15264254
Proc Natl Acad Sci U S A. 2020 Nov 3;117(44):27637-27645
pubmed: 33087569
mBio. 2017 Feb 14;8(1):
pubmed: 28196962
Annu Rev Virol. 2014 Nov;1(1):171-89
pubmed: 26958720
Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):11608-11612
pubmed: 30348794
Nat Methods. 2017 Mar;14(3):290-296
pubmed: 28165473
Am J Trop Med Hyg. 2018 May;98(5):1472-1477
pubmed: 29557336
Nature. 2021 Oct;598(7882):672-676
pubmed: 34646020
Proc Natl Acad Sci U S A. 2020 Apr 21;117(16):8890-8899
pubmed: 32245806
Viruses. 2018 Feb 22;10(2):
pubmed: 29470397
N Engl J Med. 1949 Jun 16;240(24):960-2
pubmed: 18144801
Front Microbiol. 2016 Jun 20;7:959
pubmed: 27379085
Nat Commun. 2021 Jul 7;12(1):4176
pubmed: 34234134
J Virol. 1999 Oct;73(10):8476-84
pubmed: 10482600
Antiviral Res. 2003 Jan;57(1-2):101-11
pubmed: 12615306
J Virol. 2014 Sep 1;88(17):9616-23
pubmed: 24920796
Cell. 2015 Nov 19;163(5):1095-1107
pubmed: 26553503
J Med Entomol. 2012 May;49(3):731-8
pubmed: 22679883
PLoS Pathog. 2019 Feb 11;15(2):e1007584
pubmed: 30742691
Emerg Microbes Infect. 2020 Dec;9(1):1638-1650
pubmed: 32672516
Epidemiol Infect. 2020 Apr 01;148:e72
pubmed: 32234110
Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13898-903
pubmed: 26504196
Virol J. 2015 Sep 30;12:154
pubmed: 26423229
Cell. 2021 Aug 19;184(17):4414-4429.e19
pubmed: 34416146
EMBO J. 1998 Aug 17;17(16):4585-93
pubmed: 9707418
Cell Rep. 2015 Dec 22;13(11):2553-2564
pubmed: 26686638
PLoS Pathog. 2020 May 4;16(5):e1008517
pubmed: 32365139
Nature. 2010 Dec 2;468(7324):709-12
pubmed: 21124458
J Virol. 2004 Apr;78(7):3312-8
pubmed: 15016852
Cell. 2021 Aug 19;184(17):4430-4446.e22
pubmed: 34416147
Cell. 2021 Dec 9;184(25):6052-6066.e18
pubmed: 34852239
J Mol Biol. 2007 Sep 21;372(3):774-97
pubmed: 17681537
J Exp Med. 2019 Oct 7;216(10):2282-2301
pubmed: 31337735
PLoS Pathog. 2020 Oct 22;16(10):e1008876
pubmed: 33091085
Cell Rep. 2018 Dec 11;25(11):3136-3147.e5
pubmed: 30540945
J Virol. 2002 Nov;76(22):11645-58
pubmed: 12388725
Viruses. 2018 Mar 20;10(3):
pubmed: 29558394
Science. 2015 Jul 3;349(6243):88-91
pubmed: 26138979
J Virol. 2019 Feb 5;93(4):
pubmed: 30463969
MMWR Morb Mortal Wkly Rep. 2020 Jan 17;69(2):50-51
pubmed: 31945032
Sci Transl Med. 2019 May 15;11(492):
pubmed: 31092692
Nat Microbiol. 2019 Jan;4(1):187-197
pubmed: 30455470
Viruses. 2019 Nov 19;11(11):
pubmed: 31752346
Cell. 2020 Dec 23;183(7):1884-1900.e23
pubmed: 33301709
Viruses. 2010 Mar 26;2(4):796-825
pubmed: 21546978
Cell. 2019 Jun 13;177(7):1725-1737.e16
pubmed: 31080061
N Engl J Med. 2013 May 2;368(18):1670-3
pubmed: 23635048
Cell Host Microbe. 2018 Sep 12;24(3):417-428.e5
pubmed: 30146390
Viruses. 2019 Mar 28;11(4):
pubmed: 30925717
Structure. 2006 Jan;14(1):75-86
pubmed: 16407067
EMBO J. 2011 Aug 09;30(18):3854-63
pubmed: 21829169

Auteurs

Lauren E Williamson (LE)

The Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232.
Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN 37232.

Abhishek Bandyopadhyay (A)

Purdue Institute of Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, IN 47907.
ORCID: 0000-0001-7062-4343

Kevin Bailey (K)

Institute for Antiviral Research, Utah State University, Logan, UT 84335.
ORCID: 0000-0001-6734-0024

Devika Sirohi (D)

Purdue Institute of Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, IN 47907.
ORCID: 0000-0001-8601-6211

Thomas Klose (T)

Purdue Institute of Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, IN 47907.
ORCID: 0000-0002-2150-9792

Justin G Julander (JG)

Institute for Antiviral Research, Utah State University, Logan, UT 84335.
ORCID: 0000-0001-6888-7320

Richard J Kuhn (RJ)

Purdue Institute of Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, IN 47907.
ORCID: 0000-0003-4148-1026

James E Crowe (JE)

The Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232.
Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN 37232.
Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232.
ORCID: 0000-0002-0049-1079

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Structural constraints link differences in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Perissodactyla › Equidae › Equus caballus › Structural constraints link differences in...
questionsmedicales.fr › Eucaryotes › Animaux › Structural constraints link differences in...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Togaviridae › Alphavirus › Virus de l'encéphalite équine de l'Est › Structural constraints link differences in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps neutralisants › Structural constraints link differences in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps antiviraux › Structural constraints link differences in...
questionsmedicales.fr › Techniques d'investigation › Microscopie électronique › Cryomicroscopie électronique › Structural constraints link differences in...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Épitopes › Structural constraints link differences in...
questionsmedicales.fr › Maladies du système nerveux › Encéphalomyélite › Encéphalomyélite équine › Structural constraints link differences in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps monoclonaux › Structural constraints link differences in...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Tests immunologiques › Tests sérologiques › Tests de neutralisation › Structural constraints link differences in...