Iridoid derivatives from Vitex rotundifolia L. f. with their anti-inflammatory activity.

Iridoids / pharmacology Vitex / chemistry Lipopolysaccharides / pharmacology Interleukin-8 Anti-Inflammatory Agents / pharmacology
COX-2 IL-8 production Iridoids NO production Rotundifoliin B Rotundifoliin C Rotundifoliin a Verbenaceae Vitex rotundifolia L. f. iNOS

Journal

Phytochemistry
ISSN: 1873-3700
Titre abrégé: Phytochemistry
Pays: England
ID NLM: 0151434

Informations de publication

Date de publication:
Jun 2023
Historique:
received: 26 07 2022
revised: 18 02 2023
accepted: 19 03 2023
medline: 1 5 2023
pubmed: 25 3 2023
entrez: 24 3 2023
Statut: ppublish

Résumé

Three undescribed iridoid glucosides and nine known compounds were isolated from Vitex rotundifolia L. f. Their structural elucidation was performed based on their spectroscopic data or acid hydrolysis followed by HPLC analysis and comparison of their NMR data with those reported in the literature. These iridoids were then evaluated for inflammatory effects through inhibition on NO production level in LPS-stimulated RAW264.7 cells. The active compounds, rotundifoliin C, isonishindacin A, agnuside, and eurostoside, were further investigated for their anti-inflammatory mechanisms of action on expression levels of iNOS and COX-2 proteins. In addition, V. rotundifolia fractions also significantly inhibited LPS-induced IL-8 production, with IC

Identifiants

DOI: 10.1016/j.phytochem.2023.113649 PMID: 36963708
pubmed: 36963708
pii: S0031-9422(23)00065-1
doi: 10.1016/j.phytochem.2023.113649
pii:
doi:

Substances chimiques

Iridoids 0
Lipopolysaccharides 0
Interleukin-8 0
Anti-Inflammatory Agents 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

113649

Informations de copyright

Copyright © 2023. Published by Elsevier Ltd.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Duc Dat Le (DD)

College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, 255 Jungangno, Suncheon, 57922, Jeonnam, South Korea.

Sanghee Han (S)

College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, 255 Jungangno, Suncheon, 57922, Jeonnam, South Korea.

Jayeon Yu (J)

College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, 255 Jungangno, Suncheon, 57922, Jeonnam, South Korea.

Jeongjun Ahn (J)

College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, 255 Jungangno, Suncheon, 57922, Jeonnam, South Korea.

Chang-Kwon Kim (CK)

College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, 255 Jungangno, Suncheon, 57922, Jeonnam, South Korea.

Mina Lee (M)

College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, 255 Jungangno, Suncheon, 57922, Jeonnam, South Korea. Electronic address: minalee@sunchon.ac.kr.

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrannes › Iridoïdes › Iridoid derivatives from Vitex rotundifolia L....
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Lamiales › Lamiaceae › Vitex › Iridoid derivatives from Vitex rotundifolia L....
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Toxines bactériennes › Endotoxines › Lipopolysaccharides › Iridoid derivatives from Vitex rotundifolia L....
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-8 › Iridoid derivatives from Vitex rotundifolia L....
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-inflammatoires › Iridoid derivatives from Vitex rotundifolia L....