Persistent SARS-CoV-2-specific immune defects in kidney transplant recipients following third mRNA vaccine dose.

Humans SARS-CoV-2 / genetics COVID-19 / epidemiology Kidney Transplantation / adverse effects RNA, Messenger / genetics Transplant Recipients mRNA Vaccines Receptors, Antigen, T-Cell Antibodies, Viral
SARS-CoV-2 antibody clinical trial immunogenicity kidney transplant vaccination

Journal

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
ISSN: 1600-6143
Titre abrégé: Am J Transplant
Pays: United States
ID NLM: 100968638

Informations de publication

Date de publication:
06 2023
Historique:
received: 30 01 2023
revised: 17 03 2023
accepted: 17 03 2023
medline: 6 6 2023
pubmed: 27 3 2023
entrez: 26 3 2023
Statut: ppublish

Résumé

Kidney transplant recipients (KTRs) show poorer response to SARS-CoV-2 mRNA vaccination, yet response patterns and mechanistic drivers following third doses are ill-defined. We administered third monovalent mRNA vaccines to n = 81 KTRs with negative or low-titer anti-receptor binding domain (RBD) antibody (n = 39 anti-RBD

Identifiants

DOI: 10.1016/j.ajt.2023.03.014 PMID: 36966905 PMC: PMC10037915
pubmed: 36966905
pii: S1600-6135(23)00357-X
doi: 10.1016/j.ajt.2023.03.014
pmc: PMC10037915
pii:
doi:

Substances chimiques

RNA, Messenger 0
mRNA Vaccines 0
Receptors, Antigen, T-Cell 0
Antibodies, Viral 0

Banques de données

ClinicalTrials.gov
['NCT04969263']

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

744-758

Subventions

Organisme : NIAID NIH HHS
ID : K23 AI157893
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI134591
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI070081
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI094189
Pays : United States
Organisme : NIMHD NIH HHS
ID : R01 MD011682
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI126322
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI138909
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI051731
Pays : United States
Organisme : NIAID NIH HHS
ID : K08 AI156021
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI138897
Pays : United States

Informations de copyright

Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.

Références

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Auteurs

William A Werbel (WA)

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Electronic address: wwerbel1@jhmi.edu.

Andrew H Karaba (AH)

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Teresa Po-Yu Chiang (TP)

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Allan B Massie (AB)

Department of Surgery, New York University Grossman School of Medicine, New York, New York, USA; Department of Population Health, New York University Grossman School of Medicine, New York, New York, USA.

Diane M Brown (DM)

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Natasha Watson (N)

National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

Maggie Chahoud (M)

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Elizabeth A Thompson (EA)

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Aileen C Johnson (AC)

Department of Surgery, Emory University, Atlanta, Georgia, USA.

Robin K Avery (RK)

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Willa V Cochran (WV)

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Daniel Warren (D)

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Tao Liang (T)

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Miguel Fribourg (M)

Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Christopher Huerta (C)

Department of Medicine, Emory University, Atlanta, Georgia, USA.

Hady Samaha (H)

Department of Medicine, Emory University, Atlanta, Georgia, USA.

Sabra L Klein (SL)

Department of Medicine, Emory University, Atlanta, Georgia, USA.

Maria P Bettinotti (MP)

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

William A Clarke (WA)

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Ioannis Sitaras (I)

W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Nadine Rouphael (N)

Department of Medicine, Emory University, Atlanta, Georgia, USA.

Andrea L Cox (AL)

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Medicine, Emory University, Atlanta, Georgia, USA; Bloomberg Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Justin R Bailey (JR)

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Andrew Pekosz (A)

W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Aaron A R Tobian (AAR)

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Christine M Durand (CM)

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Nancy D Bridges (ND)

National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

Christian P Larsen (CP)

Department of Surgery, Emory University, Atlanta, Georgia, USA.

Peter S Heeger (PS)

Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Dorry L Segev (DL)

Department of Surgery, New York University Grossman School of Medicine, New York, New York, USA; Department of Population Health, New York University Grossman School of Medicine, New York, New York, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Persistent SARS-CoV-2-specific immune defects...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Persistent SARS-CoV-2-specific immune defects...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Persistent SARS-CoV-2-specific immune defects...
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de chirurgie urogénitale › Procédures de chirurgie urologique › Transplantation rénale › Persistent SARS-CoV-2-specific immune defects...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › Persistent SARS-CoV-2-specific immune defects...
questionsmedicales.fr › Personnes › Receveurs de transplantation › Persistent SARS-CoV-2-specific immune defects...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Vaccins synthétiques › Vaccins à base d'acide nucléique › Vaccins à ARNm › Persistent SARS-CoV-2-specific immune defects...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux antigènes › Récepteurs aux antigènes des cellules T › Persistent SARS-CoV-2-specific immune defects...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps antiviraux › Persistent SARS-CoV-2-specific immune defects...