Ligand-gated mechanisms leading to ictogenesis in focal epileptic disorders.
Journal
Neurobiology of disease
ISSN: 1095-953X
Titre abrégé: Neurobiol Dis
Pays: United States
ID NLM: 9500169
Informations de publication
Date de publication:
05 2023
05 2023
Historique:
received:
17
01
2023
revised:
14
03
2023
accepted:
22
03
2023
medline:
18
4
2023
pubmed:
27
3
2023
entrez:
26
3
2023
Statut:
ppublish
Résumé
We review here the neuronal mechanisms that cause seizures in focal epileptic disorders and, specifically, those involving limbic structures that are known to be implicated in human mesial temporal lobe epilepsy. In both epileptic patients and animal models, the initiation of focal seizures - which are most often characterized by a low-voltage fast onset EEG pattern - is presumably dependent on the synchronous firing of GABA-releasing interneurons that, by activating post-synaptic GABA
Identifiants
pubmed: 36967064
pii: S0969-9961(23)00111-0
doi: 10.1016/j.nbd.2023.106097
pii:
doi:
Substances chimiques
Ligands
0
Receptors, GABA-A
0
gamma-Aminobutyric Acid
56-12-2
Symporters
0
Types de publication
Review
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
106097Subventions
Organisme : CIHR
ID : 8109
Pays : Canada
Organisme : CIHR
ID : PJT153310
Pays : Canada
Organisme : CIHR
ID : PJT166178
Pays : Canada
Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors have no conflict of interest to disclose.