Soluble form of the APP fragment, sAPPβ, positively regulates tau secretion.

Animals Mice Alzheimer Disease / metabolism Amyloid beta-Peptides / metabolism Amyloid beta-Protein Precursor / metabolism Amyloid Precursor Protein Secretases / metabolism Aspartic Acid Endopeptidases / metabolism Neurodegenerative Diseases tau Proteins / metabolism
APP processing Alzheimer disease Phosphorylated tau Soluble amyloid precursor protein Tau secretion

Journal

Neuroscience research
ISSN: 1872-8111
Titre abrégé: Neurosci Res
Pays: Ireland
ID NLM: 8500749

Informations de publication

Date de publication:
Aug 2023
Historique:
received: 03 11 2022
revised: 23 03 2023
accepted: 23 03 2023
medline: 3 7 2023
pubmed: 27 3 2023
entrez: 26 3 2023
Statut: ppublish

Résumé

Extracellular tau has been highlighted in the pathogenesis of Alzheimer disease (AD), which is the most common neurodegenerative disease. Pathological analyses as well as model animal studies suggest that amyloid-β peptide (Aβ) deposition facilitates the spreading of tau aggregation pathology via extracellular tau. However, the precise mechanism of tau secretion remains unknown. Here, we show that the overexpression of amyloid precursor protein (APP) enhances the secretion of tau phosphorylated at threonine 181 in mouse neuroblastoma Neuro2a cells. Moreover, we found that soluble amyloid precursor protein β (sAPPβ), which is generated by β-site APP cleaving enzyme 1 (BACE1), mediates tau secretion. Our results demonstrate that BACE1-mediated cleavage of APP plays pathological roles in AD pathogenesis by not only Aβ production, but by the spreading of tau aggregation pathology via sAPPβ in AD patients.

Identifiants

DOI: 10.1016/j.neures.2023.03.002 PMID: 36967088
pubmed: 36967088
pii: S0168-0102(23)00068-8
doi: 10.1016/j.neures.2023.03.002
pii:
doi:

Substances chimiques

Amyloid beta-Peptides 0
Amyloid beta-Protein Precursor 0
Amyloid Precursor Protein Secretases EC 3.4.-
Aspartic Acid Endopeptidases EC 3.4.23.-
tau Proteins 0
Mapt protein, mouse 0
APP protein, mouse 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

63-70

Informations de copyright

Copyright © 2023 Elsevier Ltd and Japan Neuroscience Society. All rights reserved.

Déclaration de conflit d'intérêts

Competing interests statement The authors declare no competing financial interests associated with this study.

Auteurs

Haruaki Sato (H)

Laboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.

Kensaku Kasuga (K)

Department of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan.

Noriko Isoo (N)

Department of Physiology, School of Medicine, Teikyo University, Tokyo, Japan.

Toshihiro Hayashi (T)

Department of Physiology, School of Medicine, Teikyo University, Tokyo, Japan.

Takeshi Ikeuchi (T)

Department of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan.

Yukiko Hori (Y)

Laboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan. Electronic address: yukiko-hori@mol.f.u-tokyo.ac.jp.

Taisuke Tomita (T)

Laboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan. Electronic address: taisuke@mol.f.u-tokyo.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Soluble form of the APP fragment, sAPPβ,...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Soluble form of the APP fragment, sAPPβ,...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Soluble form of the APP fragment, sAPPβ,...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Peptides bêta-amyloïdes › Soluble form of the APP fragment, sAPPβ,...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines sécrétoires inhibitrices de protéinases › Protéase nexines › Précurseur de la protéine bêta-amyloïde › Soluble form of the APP fragment, sAPPβ,...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Endopeptidases › Amyloid precursor protein secretases › Soluble form of the APP fragment, sAPPβ,...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Endopeptidases › Aspartic acid endopeptidases › Soluble form of the APP fragment, sAPPβ,...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Soluble form of the APP fragment, sAPPβ,...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Protéines associées aux microtubules › Protéines tau › Soluble form of the APP fragment, sAPPβ,...