Durability of neutralizing antibodies against yellow fever virus after vaccination in healthy adults.
Immunization
Neutralizing antibodies
Vaccine
Yellow fever
Journal
Vaccine
ISSN: 1873-2518
Titre abrégé: Vaccine
Pays: Netherlands
ID NLM: 8406899
Informations de publication
Date de publication:
24 04 2023
24 04 2023
Historique:
received:
07
06
2022
revised:
07
12
2022
accepted:
10
03
2023
medline:
19
4
2023
pubmed:
27
3
2023
entrez:
26
3
2023
Statut:
ppublish
Résumé
In accordance with the World Health Organization, one dose of yellow fever vaccine may guarantee protection lifelong in healthy adults. However, relatively little information is still available from ad hoc studies. We evaluated the persistence of neutralizing antibodies, which are considered to be an immune correlate of protection, in a large number of military personnel vaccinated up to 47 years before. Overall, 322 individuals were studied. The median time from vaccination to blood collection for neutralizing antibody evaluation was 9 years, ranging from <1 to 47 years. Of the 322 participants, 319 had neutralizing antibodies (99.1 %). The highest median PRNT
Identifiants
pubmed: 36967285
pii: S0264-410X(23)00284-0
doi: 10.1016/j.vaccine.2023.03.022
pii:
doi:
Substances chimiques
Antibodies, Neutralizing
0
Antibodies, Viral
0
Yellow Fever Vaccine
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2761-2763Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.