Transcoronary stem cell transfer and evolution of infarct-related artery atherosclerosis: evaluation with conventional and novel imaging techniques including Quantitative Virtual Histology (qVH).
atherosclerosis
progenitor cells
stem cells
transcoronary administration
Journal
Postepy w kardiologii interwencyjnej = Advances in interventional cardiology
ISSN: 1734-9338
Titre abrégé: Postepy Kardiol Interwencyjnej
Pays: Poland
ID NLM: 101272671
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
06
05
2022
accepted:
21
10
2022
entrez:
27
3
2023
pubmed:
28
3
2023
medline:
28
3
2023
Statut:
ppublish
Résumé
It has been suggested that infarct-related artery (IRA) atherosclerosis progression after stem cell transcoronary administration might represent a stem-cell mediated adverse effect. To evaluate, using conventional (quantitative coronary angiography, QCA, intravascular ultrasound - IVUS) and novel (quantitative virtual histology - qVH) tools, evolution of IRA atherosclerosis following transcoronary stem cell transfer. QCA, IVUS, VH-IVUS and qVH were performed in 22 consecutive patients (4 women) aged 59 years (data provided as median) undergoing a distal-to-stent infusion of 2.21 × 10 18.2% subjects showed absence of distal-to-stent angiographic/IVUS atherosclerotic lesion(s) at baseline and no new lesion(s) at 12-months. In the remaining cohort, there were 28 lesions by QCA (32 by IVUS) at baseline and no new lesion(s) at follow-up. Three fibroatheromas evolved (2 to calcified fibroatheroma and 1 to a fibrocalcific lesion); other plaques maintained their stable (low-risk) phenotypes. Diameter stenosis of QCA-identified lesions was 29.5 vs. 26.5% ( This study, using a range of classic and novel imaging techniques, indicates lack of any stimulatory effect of transcoronary stem cell transfer on coronary atherosclerosis. Whether, and to what extent, a moderate reduction in plaque burden and stenosis severity at 12-months results from optimized pharmacotherapy and/or stem cell transfer requires further elucidation.
Identifiants
pubmed: 36967840
doi: 10.5114/aic.2023.125609
pii: 50264
pmc: PMC10031661
doi:
Banques de données
ClinicalTrials.gov
['NCT00316381']
Types de publication
Journal Article
Langues
eng
Pagination
483-495Informations de copyright
Copyright: © 2023 Termedia Sp. z o. o.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
JACC Cardiovasc Imaging. 2012 Mar;5(3 Suppl):S1-9
pubmed: 22421222
EuroIntervention. 2010 Aug;6(3):394-9
pubmed: 20884420
Mediators Inflamm. 2012;2012:564027
pubmed: 22547906
Postepy Kardiol Interwencyjnej. 2015;11(2):100-7
pubmed: 26161101
N Engl J Med. 2011 Jan 20;364(3):226-35
pubmed: 21247313
Coron Artery Dis. 2016 Jan;27(1):5-12
pubmed: 26340545
Eur Heart J. 2022 Feb 22;43(8):716-799
pubmed: 35016208
EuroIntervention. 2009 Jun;5(2):177-89
pubmed: 20449928
Vasc Med. 2022 Dec;27(6):532-541
pubmed: 36062298
Int J Cardiol. 2023 Feb 15;373:7-16
pubmed: 36460208
Nat Rev Cardiol. 2018 Nov;15(11):659-671
pubmed: 29743563
J Am Coll Cardiol. 2009 Jul 21;54(4):293-302
pubmed: 19608026
Circ Cardiovasc Imaging. 2012 Jan;5(1):86-93
pubmed: 22109982
Circulation. 2004 Jul 20;110(3):265-70
pubmed: 15238460
Circ Cardiovasc Interv. 2022 May;15(5):e011728
pubmed: 35485232
Eur Heart J. 2006 Dec;27(24):2989-95
pubmed: 17053006
JACC Cardiovasc Imaging. 2012 Mar;5(3 Suppl):S10-8
pubmed: 22421223
JACC Cardiovasc Imaging. 2015 Oct;8(10):1180-1187
pubmed: 26481843
Med Eng Phys. 2012 Jul;34(6):702-8
pubmed: 21981807
Nat Mater. 2014 Feb;13(2):106-9
pubmed: 24452344
Cardiovasc Res. 2019 Aug 1;115(10):e96-e98
pubmed: 31334808
Kardiol Pol. 2014;72(6):479-87
pubmed: 24526550
Arterioscler Thromb Vasc Biol. 2005 Dec;25(12):2636-41
pubmed: 16195475
Circ Res. 2018 Jul 6;123(2):132-137
pubmed: 29976683
Eur Heart J. 2009 Jun;30(11):1313-21
pubmed: 19208649
Circulation. 2003 Dec 9;108(23):2839-42
pubmed: 14656923
Int J Cardiovasc Imaging. 2006 Oct;22(5):621-31
pubmed: 16575482
J Am Coll Cardiol. 1990 Jul;16(1):145-54
pubmed: 2193046
Nat Med. 2002 Apr;8(4):403-9
pubmed: 11927948
J Am Coll Cardiol. 2006 Apr 18;47(8):1727-30
pubmed: 16631016
Circulation. 2004 Jun 15;109(23):2826-31
pubmed: 15197154
Int J Cardiovasc Imaging. 2016 Jan;32(1):189-200
pubmed: 26153522
J Am Coll Cardiol. 2001 Apr;37(5):1478-92
pubmed: 11300468
Int J Cardiovasc Imaging. 2010 Dec;26(8):843-50
pubmed: 20396951
J Nucl Cardiol. 2011 Feb;18(1):104-16
pubmed: 21161463
J Cardiol. 2015 Feb;65(2):134-42
pubmed: 25242300
J Cardiovasc Med (Hagerstown). 2011 Aug;12(8):562-70
pubmed: 21709573
Eur Heart J. 2021 Dec 1;42(45):4671-4679
pubmed: 34345911
Eur Heart J Cardiovasc Imaging. 2022 Nov 07;:
pubmed: 36342269
Eur Heart J. 2009 Jan;30(1):125; author reply 125-6
pubmed: 18997176
Circulation. 2002 Oct 22;106(17):2200-6
pubmed: 12390948
Am J Cardiol. 2012 May 15;109(10):1405-10
pubmed: 22381156
EuroIntervention. 2023 Feb 06;18(13):e1099-e1107
pubmed: 36170036
Stem Cell Res Ther. 2022 Jul 18;13(1):328
pubmed: 35850768
Regen Med. 2021 Jul;16(7):669-682
pubmed: 34189963
Cardiovasc Res. 2022 Mar 16;118(4):951-976
pubmed: 33871588
Int J Cardiol. 2004 Sep;96(3):389-96
pubmed: 15301892
Nat Clin Pract Cardiovasc Med. 2008 Apr;5(4):219-29
pubmed: 18301388
J Am Coll Cardiol. 2010 Apr 13;55(15):1590-7
pubmed: 20378076
Cardiovasc Res. 2022 Jun 22;118(7):1703-1712
pubmed: 34132771
Circ Cardiovasc Imaging. 2013 Mar 1;6(2):320-8
pubmed: 23271789
J Endovasc Ther. 2013 Aug;20(4):589-94
pubmed: 23914876
EuroIntervention. 2007 May;3(1):113-20
pubmed: 19737694
Heart. 2005 Apr;91(4):448
pubmed: 15772194
Int J Mol Sci. 2019 Sep 18;20(18):
pubmed: 31540534
JACC Cardiovasc Imaging. 2011 Aug;4(8):894-901
pubmed: 21835382
Am J Physiol Heart Circ Physiol. 2008 Aug;295(2):H717-27
pubmed: 18586893
Coron Artery Dis. 2004 Feb;15(1):13-20
pubmed: 15201616
Circ J. 2006 Sep;70(9):1111-5
pubmed: 16936420
Am J Cardiol. 2013 Dec 15;112(12):1854-9
pubmed: 24063826
J Am Coll Cardiol. 2013 Mar 12;61(10):1041-51
pubmed: 23473409