Acute myocardial infarction reparation/regeneration strategy using Wharton's jelly multipotent stem cells as an 'unlimited' therapeutic agent: 3-year outcomes in a pilot cohort of the CIRCULATE-AMI trial.
LV ejection fraction
Wharton’s jelly multipotent stem cells
efficacy
infarct size
myocardial regeneration
safety
Journal
Postepy w kardiologii interwencyjnej = Advances in interventional cardiology
ISSN: 1734-9338
Titre abrégé: Postepy Kardiol Interwencyjnej
Pays: Poland
ID NLM: 101272671
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
01
11
2021
accepted:
02
03
2022
entrez:
27
3
2023
pubmed:
28
3
2023
medline:
28
3
2023
Statut:
ppublish
Résumé
CIRCULATE-AMI (NCT03404063), a cardiac magnetic resonance imaging (cMRI) infarct size-reduction-powered double-blind randomized controlled trial (RCT) of standardized Wharton jelly multipotent stem cells (WJMSCs, CardioCell Investigational Medical Product) vs. placebo (2 : 1) transcoronary transfer on acute myocardial infarction (AMI) day ~5-7, is preceded by safety and feasibility evaluation in a pilot study cohort (CIRCULATE-AMI PSC). To evaluate WJMSC transplantation safety and evolution of left ventricular (LV) remodeling in CIRCULATE-AMI PSC. In 10 consecutive patients (32-65 years, peak CK-MB 533 ±89 U/l, cMRI-LVEF 40.3 ±2.7%, cMRI-infarct size 20.1 ±2.8%), 30 × 10 WJMSC transfer was safe and occurred in the absence of coronary (TIMI-3 in all) or myocardial (corrected TIMI frame count (cTFC) 45 ±8 vs. 44 ±9, CIRCULATE-AMI PSC data suggest that WJMSC transcoronary application ~5-7 days after large AMI in humans is feasible and safe and it may be associated with a durable LVEF improvement. CIRCULATE-AMI RCT will quantify the magnitude of LV adverse remodeling attenuation with CardioCell/placebo administration.
Identifiants
pubmed: 36967843
doi: 10.5114/aic.2022.121125
pii: 48158
pmc: PMC10031665
doi:
Types de publication
Journal Article
Langues
eng
Pagination
476-482Informations de copyright
Copyright: © 2022 Termedia Sp. z o. o.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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