Small molecules targeting endocytic uptake and recycling pathways.
endocytic recycling
endocytosis
inhibitors
mechanism of action
small molecules
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2023
2023
Historique:
received:
16
12
2022
accepted:
23
02
2023
entrez:
27
3
2023
pubmed:
28
3
2023
medline:
28
3
2023
Statut:
epublish
Résumé
Over the past years a growing number of studies highlighted the pivotal role of intracellular trafficking in cell physiology. Among the distinct transport itineraries connecting the endocytic system, both internalization (endocytosis) and recycling (endocytic recycling) pathways were found fundamental to ensure cellular sensing, cell-to-cell communication, cellular division, and collective cell migration in tissue specific-contexts. Consistently, the dysregulation of endocytic trafficking pathways is correlated with several human diseases including both cancers and neurodegeneration. Aimed at suppress specific intracellular trafficking routes involved in disease onset and progression, huge efforts have been made to identify small molecule inhibitors with suitable pharmacological properties for
Identifiants
pubmed: 36968200
doi: 10.3389/fcell.2023.1125801
pii: 1125801
pmc: PMC10036367
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1125801Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2023 Placidi, Mattu, Ciardelli and Campa.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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