Loss of action-related function and connectivity in the blind extrastriate body area.
body representation
congenital blindness
extrastriate body area
neuroimaging
plasticity
resting-state fMRI
visuomotor interactions
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2023
2023
Historique:
received:
20
06
2022
accepted:
23
02
2023
entrez:
27
3
2023
pubmed:
28
3
2023
medline:
28
3
2023
Statut:
epublish
Résumé
The Extrastriate Body Area (EBA) participates in the visual perception and motor actions of body parts. We recently showed that EBA's perceptual function develops independently of visual experience, responding to stimuli with body-part information in a supramodal fashion. However, it is still unclear if the EBA similarly maintains its action-related function. Here, we used fMRI to study motor-evoked responses and connectivity patterns in the congenitally blind brain. We found that, unlike the case of perception, EBA does not develop an action-related response without visual experience. In addition, we show that congenital blindness alters EBA's connectivity profile in a counterintuitive way-functional connectivity with sensorimotor cortices dramatically decreases, whereas connectivity with perception-related visual occipital cortices remains high. To the best of our knowledge, we show for the first time that action-related functions and connectivity in the visual cortex could be contingent on visuomotor experience. We further discuss the role of the EBA within the context of visuomotor control and predictive coding theory.
Identifiants
pubmed: 36968509
doi: 10.3389/fnins.2023.973525
pmc: PMC10035577
doi:
Types de publication
Journal Article
Langues
eng
Pagination
973525Informations de copyright
Copyright © 2023 Yizhar, Tal and Amedi.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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