Improving adherence to immunosuppression after liver or kidney transplantation in individuals with impairments in personality functioning - A randomized controlled single center feasibility study.
adherence
immunosuppression
kidney transplantation
liver transplantation
multilevel intervention
Journal
Frontiers in psychology
ISSN: 1664-1078
Titre abrégé: Front Psychol
Pays: Switzerland
ID NLM: 101550902
Informations de publication
Date de publication:
2023
2023
Historique:
received:
24
01
2023
accepted:
20
02
2023
entrez:
27
3
2023
pubmed:
28
3
2023
medline:
28
3
2023
Statut:
epublish
Résumé
Although adherence to immunosuppressive medication is the key factor for long-term graft survival today, 20-70% of transplant recipients are non-adherent to their immunosuppressive medication. A prospective, randomized, controlled single-center feasibility study was designed to evaluate the impact of a step guided multicomponent interprofessional intervention program for patients after kidney or liver transplantation on adherence to their immunosuppressive medication in daily clinical practice. The intervention consisted of group therapy and daily training as well as individual sessions in a step guided approach. The primary endpoint of the study was adherence to immunosuppression as assessed with the "Basel Assessment of Adherence to Immunosuppressive Medications Scale" (BAASIS). The coefficient of variation (CV%) of Tacrolimus (TAC) through levels and the level of personality functioning was a secondary endpoint. We conducted six monthly follow-up visits. Forty-one age- and sex-matched patients [19 females, 58.5 ( The results of the feasibility study showed that this intervention program was highly accepted in the clinical setting. The Intervention group could compensate higher CV% of TAC after liver or kidney transplantation in individuals with lower levels of personality functioning and non-adherence. ClinicalTrials.gov, identifier NCT04207125.
Identifiants
pubmed: 36968754
doi: 10.3389/fpsyg.2023.1150548
pmc: PMC10033957
doi:
Banques de données
ClinicalTrials.gov
['NCT04207125']
Types de publication
Journal Article
Langues
eng
Pagination
1150548Informations de copyright
Copyright © 2023 Wagner-Skacel, Fink, Kahn, Dalkner, Jauk, Bengesser, Mairinger, Schüssler, Pieh, Stadlbauer, Kirsch, Zitta, Rosenkranz, Fickert and Schemmer.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor declared a past co-authorship with the author JW-S.
Références
Liver Transpl. 2018 Jan;24(1):80-88
pubmed: 28779546
Transplantation. 2010 Jul 27;90(2):205-19
pubmed: 20531073
Sci Rep. 2019 May 22;9(1):7734
pubmed: 31118485
J Pers Assess. 2010 Jan;92(1):35-44
pubmed: 20013454
Transplantation. 2020 Mar;104(3):640-651
pubmed: 31335759
J Investig Med. 2017 Oct;65(7):1049-1056
pubmed: 28483983
Am J Transplant. 2018 Oct;18(10):2571-2578
pubmed: 29989311
J Consult Clin Psychol. 2006 Jun;74(3):535-44
pubmed: 16822110
BMC Nephrol. 2013 May 21;14:108
pubmed: 23692889
Transplant Rev (Orlando). 2015 Apr;29(2):78-84
pubmed: 25687818
J Pers Assess. 2011 Jul;93(4):332-46
pubmed: 22804672
J Psychosom Res. 2013 Sep;75(3):229-34
pubmed: 23972411
Eur J Clin Pharmacol. 2019 Jul;75(7):951-958
pubmed: 30762079
Swiss Med Wkly. 2020 Sep 14;150:w20323
pubmed: 33022070
Am J Transplant. 2004 Sep;4(9):1509-13
pubmed: 15307839
Psychol Assess. 2011 Sep;23(3):615-25
pubmed: 21443364
Transplantation. 2018 Mar;102(3):e108-e114
pubmed: 29315140
Z Psychosom Med Psychother. 2015;61(3):262-74
pubmed: 26388057
Psychopathology. 2014;47(3):185-93
pubmed: 24192300
Front Psychiatry. 2021 Jul 06;12:671383
pubmed: 34295270
Clin Transplant. 2018 Sep;32(9):e13353
pubmed: 30022527
Diabetes Res Clin Pract. 2019 May;151:106-113
pubmed: 30959148
Psychother Psychosom Med Psychol. 2012 Jan;62(1):25-32
pubmed: 22271173
Nat Rev Nephrol. 2010 Mar;6(3):139-40
pubmed: 20186232
J Couns Psychol. 2020 Apr;67(3):326-336
pubmed: 31855024
Psychother Psychosom Med Psychol. 2018 May;68(5):185-194
pubmed: 29439280
Health Qual Life Outcomes. 2018 Feb 17;16(1):35
pubmed: 29454342
Transplantation. 2015 Feb;99(2):375-80
pubmed: 25606787
Nephrol Dial Transplant. 2015 May;30(5):752-61
pubmed: 24950938
Transplantation. 2007 Apr 15;83(7):858-73
pubmed: 17460556
Transplant Rev (Orlando). 2018 Jan;32(1):16-28
pubmed: 28495070
BMJ. 2013 Jan 08;346:e7586
pubmed: 23303884
Transplant Proc. 2008 May;40(4):938-9
pubmed: 18555084
Psychother Psychosom Med Psychol. 2013 Jun;63(6):238-46; quiz 247-9
pubmed: 23744014
Transplantation. 2020 Jul;104(7):1330-1340
pubmed: 31929426
J Psychosom Res. 2015 Nov;79(5):364-71
pubmed: 26526310
Am J Occup Ther. 2013 Mar-Apr;67(2):171-6
pubmed: 23433271
J Pers Disord. 2011 Apr;25(2):192-205
pubmed: 21466249
Syst Rev. 2017 Nov 29;6(1):236
pubmed: 29187249
Am J Kidney Dis. 2018 Jul;72(1):30-41
pubmed: 29602631
Transplantation. 2017 Apr;101(4S Suppl 2):S1-S56
pubmed: 28328734
J Pers Assess. 2018 Jan-Feb;100(1):30-42
pubmed: 28388222
Liver Transpl. 2008 Feb;14(2):159-72
pubmed: 18236389
Am J Transplant. 2009 Nov;9(11):2597-606
pubmed: 19843035
Transpl Int. 2019 Jun;32(6):614-625
pubmed: 30770608
Transplant Rev (Orlando). 2022 Jan;36(1):100671
pubmed: 34773910
J Pers Assess. 2012;94(5):522-32
pubmed: 22808938
Transpl Int. 2009 Aug;22(8):780-97
pubmed: 19386076
Pediatr Transplant. 2018 Feb;22(1):
pubmed: 29218760
Exp Clin Transplant. 2016 Jun;14(3):329-37
pubmed: 25890597