Efficacy of inhaled hydrogen on neurological outcome following brain ischaemia during post-cardiac arrest care (HYBRID II): a multi-centre, randomised, double-blind, placebo-controlled trial.
Coma
Hydrogen inhalation
Out-of-hospital cardiac arrest
Reperfusion injury
Journal
EClinicalMedicine
ISSN: 2589-5370
Titre abrégé: EClinicalMedicine
Pays: England
ID NLM: 101733727
Informations de publication
Date de publication:
Apr 2023
Apr 2023
Historique:
received:
24
11
2022
revised:
26
02
2023
accepted:
27
02
2023
entrez:
27
3
2023
pubmed:
28
3
2023
medline:
28
3
2023
Statut:
epublish
Résumé
Inhaled molecular hydrogen gas (H HYBRID II is a prospective, multicentre, randomised, double-blind, placebo-controlled trial performed at 15 hospitals in Japan, between February 1, 2017, and September 30, 2021. Patients aged 20-80 years with coma following cardiogenic OHCA were randomly assigned (1:1) using blinded gas cylinders to receive supplementary oxygen with 2% H The trial was terminated prematurely because of the restrictions imposed on enrolment during the COVID-19 pandemic. Between February 1, 2017, and September 30, 2021, 429 patients were screened for eligibility, of whom 73 were randomly assigned to H The increase in participants with good neurological outcomes following post-OHCA H Taiyo Nippon Sanso Corporation. For the Japanese translation of the abstract see Supplementary Materials section.
Sections du résumé
Background
UNASSIGNED
Inhaled molecular hydrogen gas (H
Methods
UNASSIGNED
HYBRID II is a prospective, multicentre, randomised, double-blind, placebo-controlled trial performed at 15 hospitals in Japan, between February 1, 2017, and September 30, 2021. Patients aged 20-80 years with coma following cardiogenic OHCA were randomly assigned (1:1) using blinded gas cylinders to receive supplementary oxygen with 2% H
Findings
UNASSIGNED
The trial was terminated prematurely because of the restrictions imposed on enrolment during the COVID-19 pandemic. Between February 1, 2017, and September 30, 2021, 429 patients were screened for eligibility, of whom 73 were randomly assigned to H
Interpretation
UNASSIGNED
The increase in participants with good neurological outcomes following post-OHCA H
Funding
UNASSIGNED
Taiyo Nippon Sanso Corporation.
Translation
UNASSIGNED
For the Japanese translation of the abstract see Supplementary Materials section.
Identifiants
pubmed: 36969346
doi: 10.1016/j.eclinm.2023.101907
pii: S2589-5370(23)00084-6
pmc: PMC10030910
doi:
Types de publication
Journal Article
Langues
eng
Pagination
101907Investigateurs
Ryoji Iizuka
(R)
Hiromichi Narimiya
(H)
Ryosuke Tsuruta
(R)
Kotaro Kaneda
(K)
Motoki Fujita
(M)
Junichi Sasaki
(J)
Osamu Akasaka
(O)
Keisuke Sawai
(K)
Makiko Nozaki
(M)
Hiroshi Imai
(H)
Ken Ishikura
(K)
Kaoru Ikejiri
(K)
Yasuyuki Kakihana
(Y)
Shuhei Niiyama
(S)
Takahiro Futatsuki
(T)
Masahiro Honda
(M)
Yasuhiro Ikeda
(Y)
Hideo Oka
(H)
Hideaki Yoshihara
(H)
Hirokazu Onishi
(H)
Susumu Yamashita
(S)
Koki Shimizu
(K)
Toshihiro Sakurai
(T)
Shu Yamada
(S)
Hiroshi Fukami
(H)
Nobuaki Shime
(N)
Kei Suzuki
(K)
Yasuhiro Kuroda
(Y)
Kenya Kawakita
(K)
Akio Kimura
(A)
Tatsuki Uemura
(T)
Kiyotsugu Takuma
(K)
Kunio Kanao
(K)
Youichi Yanagawa
(Y)
Ikuto Takeuchi
(I)
Informations de copyright
© 2023 The Author(s).
Déclaration de conflit d'intérêts
We declare no competing interests.
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