Prime editing in hematopoietic stem cells-From
CRISPR
HSPCs
blood disorders
hematopoietic stem cells
pegRNA
primary immunodeficiencies
prime editing
Journal
Frontiers in genome editing
ISSN: 2673-3439
Titre abrégé: Front Genome Ed
Pays: Switzerland
ID NLM: 101775540
Informations de publication
Date de publication:
2023
2023
Historique:
received:
20
01
2023
accepted:
28
02
2023
entrez:
27
3
2023
pubmed:
28
3
2023
medline:
28
3
2023
Statut:
epublish
Résumé
Prime editing of human hematopoietic stem cells has the potential to become a safe and efficient way of treating diseases of the blood directly in patients. By allowing site-targeted gene intervention without homology-directed repair donor templates and DNA double-stranded breaks, the invention of prime editing fuels the exploration of alternatives to conventional recombination-based
Identifiants
pubmed: 36969373
doi: 10.3389/fgeed.2023.1148650
pii: 1148650
pmc: PMC10036844
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1148650Informations de copyright
Copyright © 2023 Wolff and Mikkelsen.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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