Roadmap for an imaging and modelling paediatric study in rural NZ.
MRI image analysis
child health and development
computational modelling
neuroimage analysis
radiology
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2023
2023
Historique:
received:
22
11
2022
accepted:
30
01
2023
entrez:
27
3
2023
pubmed:
28
3
2023
medline:
28
3
2023
Statut:
epublish
Résumé
Our study methodology is motivated from three disparate needs: one, imaging studies have existed in silo and study organs but not across organ systems; two, there are gaps in our understanding of paediatric structure and function; three, lack of representative data in New Zealand. Our research aims to address these issues in part, through the combination of magnetic resonance imaging, advanced image processing algorithms and computational modelling. Our study demonstrated the need to take an organ-system approach and scan multiple organs on the same child. We have pilot tested an imaging protocol to be minimally disruptive to the children and demonstrated state-of-the-art image processing and personalized computational models using the imaging data. Our imaging protocol spans brain, lungs, heart, muscle, bones, abdominal and vascular systems. Our initial set of results demonstrated child-specific measurements on one dataset. This work is novel and interesting as we have run multiple computational physiology workflows to generate personalized computational models. Our proposed work is the first step towards achieving the integration of imaging and modelling improving our understanding of the human body in paediatric health and disease.
Identifiants
pubmed: 36969588
doi: 10.3389/fphys.2023.1104838
pii: 1104838
pmc: PMC10036853
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1104838Informations de copyright
Copyright © 2023 Kumar, Green, Cornfeld, Condron, Emsden, Elsayed, Zhao, Gilbert, Nash, Clark, Tawhai, Burrowes, Murphy, Tayebi, McGeown, Kwon, Shim, Wang, Choisne, Carman, Besier, Handsfield, Babarenda Gamage, Shen, Maso Talou, Safaei, Maller, Taylor, Potter, Holdsworth and Wilson.
Déclaration de conflit d'intérêts
Authors HK and JM were employed by the company GE Healthcare (Australia & New Zealand). The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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