Drug-gene Interaction Screens Coupled to Tumor Data Analyses Identify the Most Clinically Relevant Cancer Vulnerabilities Driving Sensitivity to PARP Inhibition.
Journal
Cancer research communications
ISSN: 2767-9764
Titre abrégé: Cancer Res Commun
Pays: United States
ID NLM: 9918281580506676
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
received:
17
03
2022
revised:
22
07
2022
accepted:
30
08
2022
entrez:
27
3
2023
pubmed:
28
3
2023
medline:
28
3
2023
Statut:
epublish
Résumé
PARP inhibitors (PARPi) are currently indicated for the treatment of ovarian, breast, pancreatic, and prostate cancers harboring mutations in the tumor suppressor genes This study identifies tumor genetic backgrounds where to expand the use of PARPis beyond mutations in
Identifiants
pubmed: 36969741
doi: 10.1158/2767-9764.CRC-22-0119
pii: CRC-22-0119
pmc: PMC10035383
doi:
Substances chimiques
Poly(ADP-ribose) Polymerase Inhibitors
0
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
1244-1254Informations de copyright
© 2022 The Authors; Published by the American Association for Cancer Research.
Déclaration de conflit d'intérêts
K. Jamal is an AstraZeneca employee and holds stocks and shares in the company. A. Galbiati reports personal fees from AstraZeneca during the conduct of the study; other support from AstraZeneca outside the submitted work. S. Bentouati reports personal fees from AstraZeneca during the conduct of the study; other support from AstraZeneca outside the submitted work. D. Barrell is full-time employee and shareholder of AstraZeneca. M. Ahdesmäki is an employee of and shareholder in AstraZeneca. M.J. O'Connor is a full-time employee and shareholder at AstraZeneca. J.V. Forment reports personal fees from AstraZeneca during the conduct of the study; other support from AstraZeneca outside the submitted work. No disclosures were reported by the other authors.
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