Structural MRI predicts clinical progression in presymptomatic genetic frontotemporal dementia: findings from the GENetic Frontotemporal dementia Initiative cohort.

MRI imaging brain volumetry diffusion imaging genetic frontotemporal dementia presymptomatic stage

Journal

Brain communications
ISSN: 2632-1297
Titre abrégé: Brain Commun
Pays: England
ID NLM: 101755125

Informations de publication

Date de publication:
2023
Historique:
received: 31 08 2022
revised: 22 11 2022
accepted: 08 03 2023
entrez: 27 3 2023
pubmed: 28 3 2023
medline: 28 3 2023
Statut: epublish

Résumé

Biomarkers that can predict disease progression in individuals with genetic frontotemporal dementia are urgently needed. We aimed to identify whether baseline MRI-based grey and white matter abnormalities are associated with different clinical progression profiles in presymptomatic mutation carriers in the GENetic Frontotemporal dementia Initiative. Three hundred eighty-seven mutation carriers were included (160

Identifiants

DOI: 10.1093/braincomms/fcad061 PMID: 36970046 PMC: PMC10036293
pubmed: 36970046
doi: 10.1093/braincomms/fcad061
pii: fcad061
pmc: PMC10036293
doi:

Types de publication

Journal Article

Langues

eng

Pagination

fcad061

Subventions

Organisme : Wellcome Trust
ID : 103838
Pays : United Kingdom

Investigateurs

Aitana Sogorb Esteve (AS)
Annabel Nelson (A)
Carolin Heller (C)
Caroline V Greaves (CV)
Hanya Benotmane (H)
Henrik Zetterberg (H)
Imogen J Swift (IJ)
Kiran Samra (K)
Rachelle Shafei (R)
Carolyn Timberlake (C)
Thomas Cope (T)
Timothy Rittman (T)
Alberto Benussi (A)
Enrico Premi (E)
Roberto Gasparotti (R)
Silvana Archetti (S)
Stefano Gazzina (S)
Valentina Cantoni (V)
Andrea Arighi (A)
Chiara Fenoglio (C)
Elio Scarpini (E)
Giorgio Fumagalli (G)
Vittoria Borracci (V)
Giacomina Rossi (G)
Giorgio Giaccone (G)
Giuseppe Di Fede (G)
Paola Caroppo (P)
Pietro Tiraboschi (P)
Sara Prioni (S)
Veronica Redaelli (V)
David Tang-Wai (D)
Ekaterina Rogaeva (E)
Miguel Castelo-Branco (M)
Morris Freedman (M)
Ron Keren (R)
Sandra Black (S)
Sara Mitchell (S)
Christen Shoesmith (C)
Robart Bartha (R)
Rosa Rademakers (R)
Jackie Poos (J)
Janne M Papma (JM)
Lucia Giannini (L)
Rick van Minkelen (R)
Yolande Pijnenburg (Y)
Benedetta Nacmias (B)
Camilla Ferrari (C)
Cristina Polito (C)
Gemma Lombardi (G)
Valentina Bessi (V)
Michele Veldsman (M)
Christin Andersson (C)
Hakan Thonberg (H)
Linn Öijerstedt (L)
Vesna Jelic (V)
Paul Thompson (P)
Tobias Langheinrich (T)
Albert Lladó (A)
Anna Antonell (A)
Jaume Olives (J)
Mircea Balasa (M)
Nuria Bargalló (N)
Sergi Borrego-Ecija (S)
Ana Verdelho (A)
Carolina Maruta (C)
Catarina B Ferreira (CB)
Gabriel Miltenberger (G)
Frederico Simões do Couto (F)
Alazne Gabilondo (A)
Ana Gorostidi (A)
Jorge Villanua (J)
Marta Cañada (M)
Mikel Tainta (M)
Miren Zulaica (M)
Myriam Barandiaran (M)
Patricia Alves (P)
Benjamin Bender (B)
Carlo Wilke (C)
Lisa Graf (L)
Annick Vogels (A)
Mathieu Vandenbulcke (M)
Philip Van Damme (P)
Rose Bruffaerts (R)
Koen Poesen (K)
Pedro Rosa-Neto (P)
Serge Gauthier (S)
Agnès Camuzat (A)
Alexis Brice (A)
Anne Bertrand (A)
Aurélie Funkiewiez (A)
Daisy Rinaldi (D)
Dario Saracino (D)
Olivier Colliot (O)
Sabrina Sayah (S)
Catharina Prix (C)
Elisabeth Wlasich (E)
Olivia Wagemann (O)
Sandra Loosli (S)
Sonja Schönecker (S)
Tobias Hoegen (T)
Jolina Lombardi (J)
Sarah Anderl-Straub (S)
Adeline Rollin (A)
Gregory Kuchcinski (G)
Maxime Bertoux (M)
Thibaud Lebouvier (T)
Vincent Deramecourt (V)
Beatriz Santiago (B)
Diana Duro (D)
Maria João Leitão (MJ)
Maria Rosario Almeida (MR)
Miguel Tábuas-Pereira (M)
Sónia Afonso (S)

Informations de copyright

© The Author(s) 2023. Published by Oxford University Press on behalf of the Guarantors of Brain.

Déclaration de conflit d'intérêts

The authors report no competing interests.

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Auteurs

Martina Bocchetta (M)

Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.
Centre for Cognitive and Clinical Neuroscience, Division of Psychology, Department of Life Sciences, Medicine and Life Sciences, College of Health, Brunel University London, London, United Kingdom.
ORCID: 0000-0003-1814-5024

Emily G Todd (EG)

Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.
ORCID: 0000-0003-1551-5691

Arabella Bouzigues (A)

Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.

David M Cash (DM)

Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.
Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom.
ORCID: 0000-0001-7833-616X

Jennifer M Nicholas (JM)

Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Rhian S Convery (RS)

Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.

Lucy L Russell (LL)

Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.

David L Thomas (DL)

Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.
Neuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.

Ian B Malone (IB)

Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.
ORCID: 0000-0001-7512-7856

Juan Eugenio Iglesias (JE)

Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom.
Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.

John C van Swieten (JC)

Department of Neurology and Alzheimer center, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.

Lize C Jiskoot (LC)

Department of Neurology and Alzheimer center, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.
ORCID: 0000-0002-1120-1858

Harro Seelaar (H)

Department of Neurology and Alzheimer center, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.
ORCID: 0000-0003-1989-7527

Barbara Borroni (B)

Centre for Neurodegenerative Disorders, Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
ORCID: 0000-0001-9340-9814

Daniela Galimberti (D)

Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.

Raquel Sanchez-Valle (R)

Neurology Department, Hospital Clinic, Institut d'Investigacions Biomèdiques, Barcelona, Spain.
ORCID: 0000-0001-7750-896X

Robert Laforce (R)

Clinique Interdisciplinaire de Mémoire, Département des Sciences Neurologiques, CHU de Québec, Faculté de Médecine, Université Laval, Quebec City, QC, Canada.

Fermin Moreno (F)

Hospital Universitario Donostia, San Sebastian, Spain.

Matthis Synofzik (M)

Division Translational Genomics of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research (HIH), University of Tübingen, Tübingen, Germany.
German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
ORCID: 0000-0002-2280-7273

Caroline Graff (C)

Department NVS, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden.
Unit for Hereditary Dementia, Theme Aging, Karolinska University Hospital-Solna Stockholm, Stockholm, Sweden.
ORCID: 0000-0002-9949-2951

Mario Masellis (M)

Campbell Cognitive Neurology Research Unit, Sunnybrook Research Institute, Toronto, ON, Canada.

Maria Carmela Tartaglia (MC)

Toronto Western Hospital, Tanz Centre for Research in Neurodegenerative Disease, Toronto, ON, Canada.

James B Rowe (JB)

Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust and Medical Research Council Cognition and brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom.

Rik Vandenberghe (R)

Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium.
ORCID: 0000-0001-6237-2502

Elizabeth Finger (E)

Department of Clinical Neurological Sciences, University of Western Ontario, London, ON, Canada.

Fabrizio Tagliavini (F)

Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Neurologico Carlo Besta, Milan, Italy.

Alexandre de Mendonça (A)

Faculty of Medicine, University of Lisbon, Lisbon, Portugal.

Isabel Santana (I)

Neurology Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

Chris R Butler (CR)

Department of Clinical Neurology, University of Oxford, Oxford, United Kingdom.

Simon Ducharme (S)

Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.
ORCID: 0000-0002-7309-1113

Alexander Gerhard (A)

Division of Neuroscience and Experimental Psychology, Wolfson Molecular Imaging Centre, University of Manchester, Manchester, United Kingdom.
Departments of Geriatric Medicine and Nuclear Medicine, University of Duisburg-Essen, Essen, Germany.
ORCID: 0000-0002-8071-6062

Adrian Danek (A)

Neurologische Klinik und Poliklinik, Ludwig-Maximilians-Universität, Germany.
ORCID: 0000-0001-8857-5383

Johannes Levin (J)

Neurologische Klinik und Poliklinik, Ludwig-Maximilians-Universität, Germany.
German Center for Neurodegenerative Diseases (DZNE), Germany.
Munich Cluster of Systems Neurology, Munich, Germany.

Markus Otto (M)

Department of Neurology, University Hospital Ulm, Ulm, Germany.

Sandro Sorbi (S)

Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy.

Isabelle Le Ber (I)

Sorbonne Université, Paris Brain Institute-Institut du Cerveau- ICM, Inserm U1127, CNRS UMR 7225, AP-HP-Hôpital Pitié-Salpêtrière, Paris, France.
Centre deréférence des démences rares ou précoces, IM2A, Département de Neurologie, AP-HP-Hôpital Pitié-Salpêtrière, Paris, France.
Département de Neurologie, AP-HP-Hôpital Pitié-Salpêtrière, Paris, France.

Florence Pasquier (F)

University Lille, Lille, France.
Inserm 1172, Lille, France.
CHU, CNR-MAJ, Labex Distalz, LiCENDLille, Lille, France.
ORCID: 0000-0001-9880-9788

Jonathan D Rohrer (JD)

Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.

Classifications MeSH