Longitudinal progression of choroid plexus enlargement is associated with female sex, cognitive decline and ApoE E4 homozygote status.
Alzheimer’s disease
choroid plexus
cognitive impairment
longitudinal analysis
sex differences
Journal
Frontiers in psychiatry
ISSN: 1664-0640
Titre abrégé: Front Psychiatry
Pays: Switzerland
ID NLM: 101545006
Informations de publication
Date de publication:
2023
2023
Historique:
received:
07
09
2022
accepted:
27
01
2023
entrez:
27
3
2023
pubmed:
28
3
2023
medline:
28
3
2023
Statut:
epublish
Résumé
Choroid plexus (CP)-related mechanisms have been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease. In this pilot study, we aimed to elucidate the association between longitudinal changes in CP volume, sex and cognitive impairment. We assessed longitudinal changes in CP volume in a cohort of We found an overall significant increase of CP volume in time (14.92 mm Our results contribute to potential mechanisms for sex differences in cognitive impairment with a novel finding of twice the annual choroid plexus enlargement in females and provide putative support for CP-related mechanisms of cognitive deterioration and its relationship to ApoE E4.
Identifiants
pubmed: 36970283
doi: 10.3389/fpsyt.2023.1039239
pmc: PMC10031049
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1039239Informations de copyright
Copyright © 2023 Novakova Martinkova, Ferretti, Ferrari, Lerch, Matuskova, Secnik and Hort.
Déclaration de conflit d'intérêts
MF is the Cofounder and CSO of the Women’s Brain Project. She has received personal fees for consulting from Lilly, Roche, and Lundbeck, not related to the present project. AF was employed by Women’s Brain Project. JH received consultancy and lecture fees from Biogen, Schwabe, Zentiva and holds share options in Alzheon company. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Cell Rep. 2019 Apr 23;27(4):1293-1306.e6
pubmed: 31018141
Endocrinology. 2021 Nov 1;162(11):
pubmed: 34467976
PLoS One. 2012;7(5):e37502
pubmed: 22666360
Int J Mol Sci. 2020 Sep 17;21(18):
pubmed: 32957439
J Neurol Sci. 2002 Jan 15;193(2):137-46
pubmed: 11790394
Physiol Rev. 2013 Oct;93(4):1847-92
pubmed: 24137023
Endocr Rev. 2018 Aug 1;39(4):424-439
pubmed: 29668873
EMBO Mol Med. 2016 Oct 4;8(10):1162-1183
pubmed: 27596437
Biol Sex Differ. 2020 Apr 15;11(1):17
pubmed: 32295632
Exp Biol Med (Maywood). 2018 Feb;243(3):213-221
pubmed: 29405771
Neural Regen Res. 2016 Apr;11(4):534-7
pubmed: 27212900
Science. 2014 Oct 3;346(6205):89-93
pubmed: 25147279
Fluids Barriers CNS. 2018 May 31;15(1):18
pubmed: 29848382
Psychoneuroendocrinology. 2021 Jul;129:105248
pubmed: 33962245
J Alzheimers Dis. 2020;74(4):1057-1068
pubmed: 32144979
Trends Mol Med. 2019 Sep;25(9):741-749
pubmed: 31171460
Immun Ageing. 2013 May 15;10(1):19
pubmed: 23675689
Eur J Neurol. 2020 Jun;27(6):928-943
pubmed: 32056347
PLoS One. 2015 Mar 27;10(3):e0121738
pubmed: 25815836
Cell Rep. 2018 Sep 4;24(10):2773-2783.e6
pubmed: 30184509
Cell Stem Cell. 2016 Nov 3;19(5):643-652
pubmed: 27452173
Neurobiol Aging. 2020 May;89:108-117
pubmed: 32107064
J Alzheimers Dis. 2020;78(2):627-641
pubmed: 33016923
Sci Rep. 2020 Jun 10;10(1):9391
pubmed: 32523019
Sci Rep. 2017 Jul 28;7(1):6763
pubmed: 28755001
Neuroimage Clin. 2022;33:102926
pubmed: 34972034
Nat Neurosci. 2020 Feb;23(2):167-171
pubmed: 31873194
Curr Aging Sci. 2010 Dec;3(3):219-29
pubmed: 20735345
Front Immunol. 2018 May 16;9:1066
pubmed: 29868025
J Neurosci. 2015 Sep 16;35(37):12766-78
pubmed: 26377465
Hum Brain Mapp. 2020 Dec 15;41(18):5141-5150
pubmed: 32856754
Neurology. 2015 Jul 28;85(4):331-8
pubmed: 26136516
Neurobiol Aging. 2008 Jun;29(6):902-12
pubmed: 17324488
Radiology. 2021 Oct;301(1):166-177
pubmed: 34254858
Brain Behav Immun. 2020 Jan;83:87-111
pubmed: 31560941
Nat Rev Immunol. 2016 Oct;16(10):626-38
pubmed: 27546235
Alzheimers Dement. 2023 Feb 24;:
pubmed: 36825691
Sci Rep. 2015 Sep 21;5:14329
pubmed: 26388497
Front Neuroendocrinol. 2017 Jan;44:103-121
pubmed: 27998697
Radiology. 2022 Sep;304(3):635-645
pubmed: 35579521
Ann Clin Transl Neurol. 2022 Oct;9(10):1528-1537
pubmed: 36056634
Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3251-3255
pubmed: 30718410
J Cell Mol Med. 2018 Oct;22(10):5151-5154
pubmed: 30054982
Nat Med. 2021 Sep;27(9):1592-1599
pubmed: 34446931
JCI Insight. 2019 Dec 5;4(23):
pubmed: 31647782
Neurol Neuroimmunol Neuroinflamm. 2022 Feb 25;9(3):
pubmed: 35217580
Proc Natl Acad Sci U S A. 2021 Sep 7;118(36):
pubmed: 34479997
Brain Behav Immun. 2022 Nov;106:32-39
pubmed: 35940451
Nat Commun. 2015 Aug 18;6:7967
pubmed: 26284939
Front Endocrinol (Lausanne). 2022 Oct 13;13:984929
pubmed: 36313760
Front Aging Neurosci. 2021 Sep 17;13:734992
pubmed: 34603011
J Chem Neuroanat. 2016 Dec;78:20-24
pubmed: 27475519
Front Neurosci. 2015 Jul 09;9:238
pubmed: 26217172
J Neuroinflammation. 2022 Oct 5;19(1):247
pubmed: 36199077
Front Aging. 2022 Nov 23;3:1007098
pubmed: 36506464
J Alzheimers Dis. 2019;69(1):91-109
pubmed: 30909239
Neuron. 2002 Jan 31;33(3):341-55
pubmed: 11832223
Dev Cell. 2020 Dec 7;55(5):617-628.e6
pubmed: 33038331
Alzheimers Dement. 2011 May;7(3):263-9
pubmed: 21514250
Front Cell Neurosci. 2015 Feb 06;9:17
pubmed: 25705176
Am J Psychiatry. 2019 Jul 1;176(7):564-572
pubmed: 31164007
Int J Stroke. 2019 Dec;14(9):923-930
pubmed: 31096870
Am J Anat. 1970 May;128(1):73-95
pubmed: 4193921
Fluids Barriers CNS. 2020 Feb 5;17(1):14
pubmed: 32024544
Int J Mol Sci. 2018 Jan 17;19(1):
pubmed: 29342116
Int J Geriatr Psychiatry. 1999 Oct;14(10):858-65
pubmed: 10521885
Nature. 2021 Jul;595(7868):565-571
pubmed: 34153974