Analysis of 2'-hydroxyflavanone (2HF) in mouse whole blood by HPLC-MS/MS for the determination of pharmacokinetic parameters.
2′-hydroxiflavanone
HPLC-MS/MS
flavonoid
oral treatment
pharmacokinetics
Journal
Frontiers in chemistry
ISSN: 2296-2646
Titre abrégé: Front Chem
Pays: Switzerland
ID NLM: 101627988
Informations de publication
Date de publication:
2023
2023
Historique:
received:
12
10
2022
accepted:
13
02
2023
entrez:
27
3
2023
pubmed:
28
3
2023
medline:
28
3
2023
Statut:
epublish
Résumé
Given the lack of investments, structure, and difficulty of metabolite isolation, promising natural product studies do not progress to preclinical studies, such as pharmacokinetics. 2'-Hydroxyflavanone (2HF) is a flavonoid that has shown promising results in different types of cancer and leishmaniasis. For accurate quantification of 2HF in BALB/c mouse blood, a validated HPLC-MS/MS method was developed. Chromatographic analysis was performed using C
Identifiants
pubmed: 36970405
doi: 10.3389/fchem.2023.1016193
pii: 1016193
pmc: PMC10033538
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1016193Informations de copyright
Copyright © 2023 Gervazoni, Gonçalves-Ozorio, Ferreira-Paes, Silva, Silveira, Pereira, Pinto, Cunha-Junior and Almeida-Amaral.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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