Inactivation of
Journal
Cancer research communications
ISSN: 2767-9764
Titre abrégé: Cancer Res Commun
Pays: United States
ID NLM: 9918281580506676
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
received:
08
03
2022
revised:
17
09
2022
accepted:
10
11
2022
entrez:
27
3
2023
pubmed:
28
3
2023
medline:
28
3
2023
Statut:
epublish
Résumé
Expression of the Notch family of receptors is often upregulated in pancreatic ductal adenocarcinoma (PDAC). In this study, we focused on Notch4, which had not been investigated in PDAC. We generated KC ( We demonstrated that global inactivation of
Identifiants
pubmed: 36970723
doi: 10.1158/2767-9764.CRC-22-0106
pii: CRC-22-0106
pmc: PMC10035463
doi:
Substances chimiques
Proto-Oncogene Proteins p21(ras)
EC 3.6.5.2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
1601-1616Subventions
Organisme : NCI NIH HHS
ID : R01 CA267870
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA217207
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA013696
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA259715
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA240654
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL112626
Pays : United States
Informations de copyright
© 2022 The Authors; Published by the American Association for Cancer Research.
Déclaration de conflit d'intérêts
I. Chio reports grants from NCI during the conduct of the study. C.J. Shawber reports a patent to Composition of humanized NOTCH fusion proteins and methods of treatment. United States Patent No: 20110008342 A1, January 13, 2011 issued. J. Kitajewski reports grants from the NIH/NHLBI during the conduct of the study. G.H. Su reports grants from NIH/NCI, Pancreatic Cancer Action Network, and Robert L. Fine Cancer Research Foundation during the conduct of the study. No disclosures were reported by the other authors.
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