The Mediator subunit MED12 promotes formation of HSF1 condensates on heat shock response element arrays in heat-shocked cells.
HSF1
MED12
heat shock
phase separation
reporter array
transcription
Journal
FEBS letters
ISSN: 1873-3468
Titre abrégé: FEBS Lett
Pays: England
ID NLM: 0155157
Informations de publication
Date de publication:
07 2023
07 2023
Historique:
revised:
05
03
2023
received:
28
12
2022
accepted:
14
03
2023
medline:
12
7
2023
pubmed:
28
3
2023
entrez:
27
3
2023
Statut:
ppublish
Résumé
Upon heat shock, activated heat shock transcription factor 1 (HSF1) binds to the heat shock response elements (HSEs) in the promoters of mammalian heat shock protein (HSP)-encoding genes and recruits the preinitiation complex and coactivators, including Mediator. These transcriptional regulators may be concentrated in phase-separated condensates around the promoters, but they are too minute to be characterized in detail. We herein established HSF1
Identifiants
pubmed: 36971000
doi: 10.1002/1873-3468.14617
doi:
Substances chimiques
Heat Shock Transcription Factors
0
DNA-Binding Proteins
0
Transcription Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1702-1717Informations de copyright
© 2023 Federation of European Biochemical Societies.
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