Investigating TSPO levels in occupation-related posttraumatic stress disorder.

Child, Preschool Humans Male Stress Disorders, Post-Traumatic / diagnostic imaging Hydrocortisone / metabolism Brain / diagnostic imaging Anxiety Disorders / metabolism Positron-Emission Tomography / methods Receptors, GABA / metabolism Occupations

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
27 03 2023
Historique:
received: 09 12 2022
accepted: 09 03 2023
medline: 29 3 2023
entrez: 27 3 2023
pubmed: 28 3 2023
Statut: epublish

Résumé

Microglia are immune brain cells implicated in stress-related mental illnesses including posttraumatic stress disorder (PTSD). Their role in the pathophysiology of PTSD, and on neurobiological systems that regulate stress, is not completely understood. We tested the hypothesis that microglia activation, in fronto-limbic brain regions involved in PTSD, would be elevated in participants with occupation-related PTSD. We also explored the relationship between cortisol and microglia activation. Twenty participants with PTSD and 23 healthy controls (HC) completed positron emission tomography (PET) scanning of the 18-kDa translocator protein (TSPO), a putative biomarker of microglia activation using the probe [

Identifiants

DOI: 10.1038/s41598-023-31327-y PMID: 36973385 PMC: PMC10041517
pubmed: 36973385
doi: 10.1038/s41598-023-31327-y
pii: 10.1038/s41598-023-31327-y
pmc: PMC10041517
doi:

Substances chimiques

Hydrocortisone WI4X0X7BPJ
Receptors, GABA 0
TSPO protein, human 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4970

Informations de copyright

© 2023. The Author(s).

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Auteurs

Sarah E Watling (SE)

Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada.
Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada.

Talwinder Gill (T)

Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada.
Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada.

Erin V Gaudette (EV)

Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada.
Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada.

J Don Richardson (JD)

The MacDonald Franklin OSI Research Centre, Lawson Health Research Institute, London, ON, Canada.
Department of Psychiatry, University of Western Ontario, London, ON, Canada.
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
St Joseph's, London OSI, Parkwood Institute, St. Joseph's Health Care, London, ON, Canada.

Tina McCluskey (T)

Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Campbell Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.

Junchao Tong (J)

Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Campbell Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Department of Psychiatry, University of Toronto, Toronto, ON, Canada.

Jeffrey H Meyer (JH)

Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada.
Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Campbell Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.

Jerry Warsh (J)

Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada.
Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Campbell Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.

Rakesh Jetly (R)

Directorate of Mental Health, Canadian Forces Health Services, Ottawa, ON, Canada.
Department of Psychiatry, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Department of Psychiatry, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.

Michael G Hutchison (MG)

Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON, Canada.
David L. MacIntosh Sport Medicine Clinic, Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON, Canada.
Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.

Shawn G Rhind (SG)

Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON, Canada.
Defence Research and Development Canada, Toronto Research Centre, Toronto, ON, Canada.

Sylvain Houle (S)

Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Campbell Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Department of Psychiatry, University of Toronto, Toronto, ON, Canada.

Stephen J Kish (SJ)

Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada.
Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Campbell Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.

Isabelle Boileau (I)

Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada. isabelle.boileau@camh.ca.
Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada. isabelle.boileau@camh.ca.
Campbell Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada. isabelle.boileau@camh.ca.
Department of Psychiatry, University of Toronto, Toronto, ON, Canada. isabelle.boileau@camh.ca.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Enfant d'âge préscolaire › Investigating TSPO levels in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Investigating TSPO levels in...
questionsmedicales.fr › Troubles mentaux › Troubles liés aux traumatismes et au stress › Troubles de stress traumatique › Troubles de stress post-traumatique › Investigating TSPO levels in...
questionsmedicales.fr › Hormones corticosurrénaliennes › Hydroxycorticostéroïdes › 17-Hydroxycorticostéroïdes › Hydrocortisone › Investigating TSPO levels in...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Investigating TSPO levels in...
questionsmedicales.fr › Troubles mentaux › Troubles anxieux › Investigating TSPO levels in...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Investigating TSPO levels in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs aux acides aminés › Récepteurs GABA › Investigating TSPO levels in...
questionsmedicales.fr › Caractéristiques de la population › Facteurs socioéconomiques › Professions › Investigating TSPO levels in...