The role of rare genetic variants enrichment in epilepsies of presumed genetic etiology.


Journal

medRxiv : the preprint server for health sciences
Titre abrégé: medRxiv
Pays: United States
ID NLM: 101767986

Informations de publication

Date de publication:
10 Mar 2023
Historique:
medline: 29 3 2023
entrez: 28 3 2023
pubmed: 29 3 2023
Statut: epublish

Résumé

Previous studies suggested that severe epilepsies e.g., developmental and epileptic encephalopathies (DEE) are mainly caused by ultra-rare

Identifiants

pubmed: 36974069
doi: 10.1101/2023.01.17.23284702
pmc: PMC10041669
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NHGRI NIH HHS
ID : U01 HG009088
Pays : United States
Organisme : NHGRI NIH HHS
ID : UM1 HG008895
Pays : United States

Commentaires et corrections

Type : UpdateIn

Déclaration de conflit d'intérêts

11.Conflict of Interest The authors declare no competing interests.

Références

Brain. 2019 Nov 1;142(11):3473-3481
pubmed: 31608925
Bioinformatics. 2011 Jun 15;27(12):1739-40
pubmed: 21546393
EBioMedicine. 2022 Jul;81:104098
pubmed: 35679801
Neurology. 1982 Feb;32(2):174-9
pubmed: 7198743
Nat Methods. 2017 Jan;14(1):61-64
pubmed: 27892958
Nat Rev Dis Primers. 2018 May 03;4:18024
pubmed: 29722352
J Neurocytol. 1996 Sep;25(9):535-46
pubmed: 8910799
J Cell Sci. 2012 Aug 15;125(Pt 16):3858-69
pubmed: 22595522
Nature. 2009 Oct 8;461(7265):747-53
pubmed: 19812666
Science. 2020 Mar 6;367(6482):
pubmed: 32139519
J Neuromuscul Dis. 2021;8(s2):S243-S255
pubmed: 34633328
PLoS Comput Biol. 2021 Sep 7;17(9):e1009105
pubmed: 34492007
Nat Genet. 2022 Sep;54(9):1320-1331
pubmed: 35982160
Am J Hum Genet. 2019 Aug 1;105(2):267-282
pubmed: 31327507
Genome Res. 2007 Oct;17(10):1537-45
pubmed: 17785539
BMC Genomics. 2021 Nov 7;22(1):802
pubmed: 34743696
Bioinformatics. 2016 Oct 15;32(20):3201-3203
pubmed: 27354695
Epilepsia. 2022 Jun 29;:
pubmed: 35767389
Brain. 2014 Mar;137(Pt 3):795-805
pubmed: 24468822
Prog Brain Res. 2014;214:229-62
pubmed: 25410361
Prog Neurobiol. 2009 Jan 12;87(1):41-57
pubmed: 18952142
Annu Rev Genomics Hum Genet. 2020 Aug 31;21:205-230
pubmed: 32339036
Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):E455-64
pubmed: 24443550
Front Pharmacol. 2018 Sep 18;9:974
pubmed: 30283332
Mol Cell Neurosci. 2009 Nov;42(3):219-25
pubmed: 19607921
Genome Biol. 2016 Jun 06;17(1):122
pubmed: 27268795
Skelet Muscle. 2015 Dec 21;5:43
pubmed: 26693275
MMWR Morb Mortal Wkly Rep. 2017 Aug 11;66(31):821-825
pubmed: 28796763
Development. 2015 Aug 15;142(16):2781-91
pubmed: 26209645
Front Neurol. 2021 Mar 09;12:632336
pubmed: 33767660
Methods Mol Biol. 2007;376:71-84
pubmed: 17984539
Hum Genome Var. 2020 Dec 3;7(1):43
pubmed: 33298907
J Cell Sci. 2012 Apr 15;125(Pt 8):2017-29
pubmed: 22328498
Nature. 2012 Sep 20;489(7416):391-399
pubmed: 22996553
Neuroscience. 2004;129(2):309-24
pubmed: 15501589
Transl Stroke Res. 2021 Feb;12(1):72-86
pubmed: 32253702
Neuron Glia Biol. 2008 Aug;4(3):235-47
pubmed: 19497143
Neurology. 2021 Oct 26;97(17):817-831
pubmed: 34493617
Nature. 2014 Apr 10;508(7495):199-206
pubmed: 24695229
Bioinformatics. 2005 May 1;21(9):1943-9
pubmed: 15647293
Nat Commun. 2018 Dec 10;9(1):5269
pubmed: 30531953
Bioinformatics. 2020 Apr 15;36(8):2628-2629
pubmed: 31882993
Genet Med. 2022 Feb;24(2):319-331
pubmed: 34906466
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
Seizure. 2017 Jan;44:11-20
pubmed: 28007376
Ann Clin Transl Neurol. 2016 Dec 20;4(1):26-35
pubmed: 28078312
Neuropsychiatr Dis Treat. 2017 Jul 13;13:1841-1859
pubmed: 28761347
Cell Death Dis. 2022 Jul 16;13(7):616
pubmed: 35842432
Nat Genet. 2019 Sep;51(9):1349-1355
pubmed: 31477931
Cell Mol Neurobiol. 2022 Apr;42(3):647-664
pubmed: 33128689
Prog Neurobiol. 2015 Nov;134:36-54
pubmed: 26386135
Lancet Neurol. 2014 Sep;13(9):893-903
pubmed: 25087078
Pharmacol Rev. 2018 Jan;70(1):142-173
pubmed: 29263209
Nat Genet. 2014 Mar;46(3):310-5
pubmed: 24487276
Lancet Neurol. 2017 Feb;16(2):135-143
pubmed: 28102150

Auteurs

Linnaeus Bundalian (L)

Institute of Human Genetics, University of Leipzig Medical Center, 4103 Leipzig, Germany.

Yin-Yuan Su (YY)

Institute of Biomedical Informatics, National Yang Ming Chiao Tung University, Taipei, Taiwan.

Siwei Chen (S)

Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Akhil Velluva (A)

Division of General Biochemistry, Rudolf Schönheimer Institute of Biochemistry, Medical Faculty, Leipzig University, 04103, Leipzig, Germany.
Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, 04103, Leipzig, Germany.

Anna Sophia Kirstein (AS)

Pediatric Research Center, University Hospital for Children and Adolescents, Leipzig University, 04103, Leipzig, Germany.

Antje Garten (A)

Pediatric Research Center, University Hospital for Children and Adolescents, Leipzig University, 04103, Leipzig, Germany.

Saskia Biskup (S)

CeGaT GmbH, 72076, Tuebingen, Germany.
Hertie-Institute for Clinical Brain Research, 72070, Tubingen, Germany.

Florian Battke (F)

CeGaT GmbH, 72076, Tuebingen, Germany.

Dennis Lal (D)

Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Cologne Center for Genomics, University of Cologne, 50937 Cologne, Germany.

Henrike O Heyne (HO)

Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Hasso-Plattner-Institut for Digital Engineering, University of Potsdam, Potsdam, Germany.
Hasso Plattner Institute at Mount Sinai, Mount Sinai School of Medicine, NY, US.
Institute for Molecular Medicine Finland: FIMM, University of Helsinki, Helsinki, Finland.

Konrad Platzer (K)

Institute of Human Genetics, University of Leipzig Medical Center, 4103 Leipzig, Germany.

Chen-Ching Lin (CC)

Institute of Biomedical Informatics, National Yang Ming Chiao Tung University, Taipei, Taiwan.

Johannes R Lemke (JR)

Institute of Human Genetics, University of Leipzig Medical Center, 4103 Leipzig, Germany.
Center for Rare Diseases, University of Leipzig Medical Center, 4103 Leipzig, Germany.

Diana Le Duc (D)

Institute of Human Genetics, University of Leipzig Medical Center, 4103 Leipzig, Germany.
Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, 04103, Leipzig, Germany.

Classifications MeSH