Development of tLyP-1 functionalized nanoliposomes with tunable internal water phase for glioma targeting.

Rats Mice Animals Endothelial Cells Liposomes Glioma / drug therapy Polyethylene Glycols / chemistry Temozolomide Cell Line, Tumor
Internal water phase nanoliposome preparation tLyP-1 target delivery

Journal

Journal of liposome research
ISSN: 1532-2394
Titre abrégé: J Liposome Res
Pays: England
ID NLM: 9001952

Informations de publication

Date de publication:
Dec 2023
Historique:
medline: 30 11 2023
pubmed: 29 3 2023
entrez: 28 3 2023
Statut: ppublish

Résumé

tLyP-1 peptide is verified to recognize neuropilin (NRP) receptors overexpressed on the surface of both glioma cells and endothelial cells of angiogenic blood vessels. In the present study, tLyP-1 was conjugated with DSPE-PEG2000 to prepare tLyP-1-DSPE-PEG2000, which was further employed to prepare tLyP-1 functionalized nanoliposome (tLyP-1-Lip) to achieve enhancing target of glioblastoma. Process parameters were systematically studied to investigate the feasibility of tuning the internal water phase of nanoliposomes and encapsulating more Temozolomide (TMZ). The particle size, Zeta potential, and encapsulation efficiency of tLyP-1-Lip/TMZ were fully characterized in comparison with conventional nanoliposomes (Lip-TMZ) and PEGylated nanoliposomes (PEG-Lip/TMZ). The release behaviors of TMZ from PEG-Lip/TMZ and tLyP-1-Lip/TMZ are similar and slower than TMZ-Lip in acidic solutions. The tLyP-1-Lip/TMZ demonstrated the strongest cytotoxicity in comparison with TMZ-Lip and PEG-Lip/TMZ in both U87 and HT22 cells, and displayed the highest cellular internalization. The pharmacokinetic studies in rats revealed that tLyP-1-Lip/TMZ showed a 1.4-fold (

Identifiants

DOI: 10.1080/08982104.2023.2191718 PMID: 36974836
pubmed: 36974836
doi: 10.1080/08982104.2023.2191718
doi:

Substances chimiques

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy-poly(ethylene glycol 2000) 0
Liposomes 0
Polyethylene Glycols 3WJQ0SDW1A
Temozolomide YF1K15M17Y

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

353-367

Auteurs

Yajing Wang (Y)

Department of Pharmacy, School of Pharmacy, Changzhou University, Changzhou, PR China.

Ziwei Ding (Z)

Department of Pharmacy, School of Pharmacy, Changzhou University, Changzhou, PR China.

Shiqun Lv (S)

Department of Pharmacy, School of Pharmacy, Changzhou University, Changzhou, PR China.

Jie Liu (J)

Department of Pharmacy, School of Pharmacy, Changzhou University, Changzhou, PR China.

Jie Pan (J)

Medical Research Center, The Affiliated Hospital of Nanjing Medical University, People's Hospital, Changzhou, PR China.

Yingcong Yu (Y)

WenzhouPeople'sHospital, Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou, PRChina.

Jun Gao (J)

Department of Orthopaedics, Changzhou Chinese Traditional Medicine Hospital, Changzhou, PR China.

Xianfeng Huang (X)

Department of Pharmacy, School of Pharmacy, Changzhou University, Changzhou, PR China.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Development of tLyP-1 functionalized...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Development of tLyP-1 functionalized...
questionsmedicales.fr › Eucaryotes › Animaux › Development of tLyP-1 functionalized...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › Development of tLyP-1 functionalized...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomimétiques › Membrane artificielle › Liposomes › Development of tLyP-1 functionalized...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Gliome › Development of tLyP-1 functionalized...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Polyéthylène glycols › Development of tLyP-1 functionalized...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Imidazoles › Dacarbazine › Témozolomide › Development of tLyP-1 functionalized...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Development of tLyP-1 functionalized...