Effect of Passive Administration of Monoclonal Antibodies Recognizing Simian Immunodeficiency Virus (SIV) V2 in CH59-Like Coil/Helical or β-Sheet Conformations on Time of SIV
Simian Immunodeficiency Virus
/ immunology
Antibodies, Monoclonal
/ administration & dosage
Viral Proteins
/ chemistry
Epitopes
/ immunology
Simian Acquired Immunodeficiency Syndrome
/ immunology
Protein Structure, Tertiary
Models, Molecular
CHO Cells
Cricetulus
Animals
Macaca
/ immunology
Antibodies, Viral
/ blood
CH59
NCI05
NCI09
V2
monoclonal antibodies
simian immunodeficiency virus
trogocytosis
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
27 04 2023
27 04 2023
Historique:
medline:
4
5
2023
pubmed:
29
3
2023
entrez:
28
3
2023
Statut:
ppublish
Résumé
The monoclonal antibodies (MAbs) NCI05 and NCI09, isolated from a vaccinated macaque that was protected from multiple simian immunodeficiency virus (SIV) challenges, both target an overlapping, conformationally dynamic epitope in SIV envelope variable region 2 (V2). Here, we show that NCI05 recognizes a CH59-like coil/helical epitope, whereas NCI09 recognizes a β-hairpin linear epitope.
Identifiants
pubmed: 36976017
doi: 10.1128/jvi.01864-22
pmc: PMC10134845
doi:
Substances chimiques
Antibodies, Monoclonal
0
Viral Proteins
0
Epitopes
0
Antibodies, Viral
0
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0186422Subventions
Organisme : NIAID NIH HHS
ID : R01 AI148379
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR028976
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI167732
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI155163
Pays : United States
Organisme : NIH HHS
ID : S10 OD027000
Pays : United States