Diverticular Disease and Rifaximin: An Evidence-Based Review.
acute diverticulitis
diverticular bleeding
diverticular disease
diverticulitis prevention
diverticulitis prophylaxis
diverticulosis
fiber supplementation
microbiota
rifaximin
Journal
Antibiotics (Basel, Switzerland)
ISSN: 2079-6382
Titre abrégé: Antibiotics (Basel)
Pays: Switzerland
ID NLM: 101637404
Informations de publication
Date de publication:
23 Feb 2023
23 Feb 2023
Historique:
received:
31
01
2023
revised:
20
02
2023
accepted:
21
02
2023
medline:
30
3
2023
entrez:
29
3
2023
pubmed:
30
3
2023
Statut:
epublish
Résumé
There have been considerable advances in the treatment of diverticular disease in recent years. Antibiotics are frequently used to treat symptoms and prevent complications. Rifaximin, a non-absorbable antibiotic, is a common therapeutic choice for symptomatic diverticular disease in various countries, including Italy. Because of its low systemic absorption and high concentration in stools, it is an excellent medicine for targeting the gastrointestinal tract, where it has a beneficial effect in addition to its antibacterial properties. Current evidence shows that cyclical rifaximin usage in conjunction with a high-fiber diet is safe and effective for treating symptomatic uncomplicated diverticular disease, while the cost-effectiveness of long-term treatment is unknown. The use of rifaximin to prevent recurrent diverticulitis is promising, but further studies are needed to confirm its therapeutic benefit. Unfortunately, there is no available evidence on the efficacy of rifaximin treatment for acute uncomplicated diverticulitis.
Identifiants
pubmed: 36978310
pii: antibiotics12030443
doi: 10.3390/antibiotics12030443
pmc: PMC10044695
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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