Exploratory Study on Chemosensory Event-Related Potentials in Long COVID-19 and Mild Cognitive Impairment: A Common Pathway?
CSERP
EEG
Long Covid
MCI
OERP
anosmia
biomarkers
left frontoparietal network
neuro-olfactometry
Journal
Bioengineering (Basel, Switzerland)
ISSN: 2306-5354
Titre abrégé: Bioengineering (Basel)
Pays: Switzerland
ID NLM: 101676056
Informations de publication
Date de publication:
19 Mar 2023
19 Mar 2023
Historique:
received:
10
02
2023
revised:
13
03
2023
accepted:
17
03
2023
medline:
30
3
2023
entrez:
29
3
2023
pubmed:
30
3
2023
Statut:
epublish
Résumé
People affected by the Long COVID-19 (LC) syndrome often show clinical manifestations that are similar to those observed in patients with mild cognitive impairments (MCI), such as olfactory dysfunction (OD), brain fog, and cognitive and attentional diseases. This study aimed to investigate the chemosensory-evoked related potentials (CSERP) in LC and MCI to understand if there is a common pathway for the similarity of symptoms associated with these disorders. Eighteen LC patients (mean age 53; s.d. = 7), 12 patients diagnosed with MCI (mean age 67; s.d. = 6), and 10 healthy control subjects (mean age 66; s.d. = 5, 7) were recruited for this exploratory study. All of them performed a chemosensory event-related potentials (CSERP) task with the administration of trigeminal stimulations (e.g., the odorants cinnamaldehyde and eucalyptus). Study results highlighted that MCI and LC showed reduced N1 amplitude, particularly in the left frontoparietal network, involved in working memory and attentional deficits, and a reduction of P3 latency in LC. This study lays the foundations for evaluating aspects of LC as a process that could trigger long-term functional alterations, and CSERPs could be considered valid biomarkers for assessing the progress of OD and an indicator of other impairments (e.g., attentional and cognitive impairments), as they occur in MCI.
Identifiants
pubmed: 36978767
pii: bioengineering10030376
doi: 10.3390/bioengineering10030376
pmc: PMC10045951
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Regione Puglia
ID : RIPARTI - Procedure Number: A9 Project Code: 77e95c8d
Références
Viruses. 2019 Dec 20;12(1):
pubmed: 31861926
Rhinology. 2021 Dec 1;59(6):517-527
pubmed: 34553706
Chem Senses. 2013 Feb;38(2):161-6
pubmed: 23118203
Front Public Health. 2021 Mar 26;9:636089
pubmed: 33842419
Chem Senses. 2021 Jan 1;46:
pubmed: 34351415
Int J Psychophysiol. 2000 May;36(2):133-45
pubmed: 10742568
Int J Psychophysiol. 2014 Sep;93(3):305-10
pubmed: 24952214
Clin Electroencephalogr. 1998 Apr;29(2):96-100
pubmed: 9571297
Front Neurosci. 2021 Aug 02;15:642584
pubmed: 34408620
Acta Med Port. 2020 May 4;33(5):356-357
pubmed: 32293558
Int J Psychophysiol. 2015 Mar;95(3):388-94
pubmed: 25697131
Brain Imaging Behav. 2018 Oct;12(5):1259-1270
pubmed: 29152692
Brain Sci. 2022 Mar 24;12(4):
pubmed: 35447962
Laryngoscope. 2019 Feb;129(2):362-369
pubmed: 30565695
J Alzheimers Dis. 2023;91(3):915-922
pubmed: 36565128
Lipids Health Dis. 2012 Aug 31;11:107
pubmed: 22937812
Laryngoscope. 2015 Aug;125(8):1763-6
pubmed: 26031472
Int J Mol Sci. 2021 Feb 08;22(4):
pubmed: 33567524
Brain Sci. 2020 Mar 30;10(4):
pubmed: 32235515
Alzheimers Dement. 2011 May;7(3):270-9
pubmed: 21514249
Electroencephalogr Clin Neurophysiol. 1998 Mar;108(2):208-17
pubmed: 9566634
Front Psychol. 2014 Feb 07;5:20
pubmed: 24570664
J Neural Transm (Vienna). 2022 Sep;129(9):1155-1167
pubmed: 35434769
Respir Physiol Neurobiol. 2019 Jan;259:37-44
pubmed: 30006255
Brain Sci. 2021 Feb 27;11(3):
pubmed: 33673697
Brain Sci. 2011 Oct 28;1(1):3-15
pubmed: 24962612
J Alzheimers Dis. 2022;88(2):399-416
pubmed: 35599487
Int J Psychophysiol. 2010 Nov;78(2):190-9
pubmed: 20688110
EClinicalMedicine. 2022 Sep 17;53:101651
pubmed: 36133318
Front Aging Neurosci. 2018 Sep 13;10:272
pubmed: 30271339
Neurol Sci. 2004 Dec;25(5):289-95
pubmed: 15624087
Neurol Sci. 2021 Dec;42(12):4921-4926
pubmed: 34557966
J Alzheimers Dis. 2010;22(4):1081-7
pubmed: 20930316
Nature. 2022 Apr;604(7907):697-707
pubmed: 35255491
Brain Sci. 2019 Apr 15;9(4):
pubmed: 30991670
Am J Rhinol Allergy. 2022 Sep;36(5):668-683
pubmed: 35585698
Int J Psychophysiol. 2000 May;36(2):105-22
pubmed: 10742566
Cortex. 2022 Jul;152:77-97
pubmed: 35537236
Chem Senses. 2018 Feb 2;43(2):89-96
pubmed: 29145567
Acta Otorhinolaryngol Ital. 2021 Aug;41(4):336-347
pubmed: 34533537
Front Behav Neurosci. 2019 Sep 26;13:226
pubmed: 31616263
Int J Soc Psychiatry. 2020 Nov;66(7):666-674
pubmed: 32489136
Chem Senses. 1997 Feb;22(1):39-52
pubmed: 9056084
Eur J Radiol. 2021 Nov;144:109985
pubmed: 34619619
Acad Radiol. 2021 Jan;28(1):28-35
pubmed: 33132007
J Alzheimers Dis. 2017;58(4):1283-1292
pubmed: 28550252
Front Aging Neurosci. 2021 Nov 22;13:737281
pubmed: 34880743
ACS Chem Neurosci. 2021 Oct 20;12(20):3795-3805
pubmed: 34609841
Brain Res. 2019 Nov 1;1722:146365
pubmed: 31400310
Psychiatry Res Neuroimaging. 2017 Feb 28;260:23-28
pubmed: 28012423
Neurocrit Care. 2021 Jun;34(3):1062-1071
pubmed: 32661794
J Alzheimers Dis. 2022;85(2):745-754
pubmed: 34864678
Gerontology. 2015;61(6):485-90
pubmed: 25968962
Psychophysiology. 2013 Aug;50(8):743-57
pubmed: 23730815
Clin Neurophysiol. 2004 Apr;115(4):732-44
pubmed: 15003751
Sci Pharm. 2016 Nov 29;84(4):724-751
pubmed: 27916830
Front Aging Neurosci. 2021 Oct 07;13:737359
pubmed: 34690743
Lancet Psychiatry. 2022 Oct;9(10):815-827
pubmed: 35987197
Chem Senses. 2018 Sep 22;43(8):611-616
pubmed: 30052799
Arch Gerontol Geriatr. 2021 Mar-Apr;93:104299
pubmed: 33285424
Brain Sci. 2022 Oct 14;12(10):
pubmed: 36291323
Int J Psychophysiol. 2022 Jul;177:213-219
pubmed: 35618112