Nrf2 Activation Does Not Protect from Aldosterone-Induced Kidney Damage in Mice.
Keap1 knockdown
aldosterone
hypertension
kidney injury
oxidative stress
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
22 Mar 2023
22 Mar 2023
Historique:
received:
03
01
2023
revised:
10
02
2023
accepted:
21
03
2023
medline:
30
3
2023
entrez:
29
3
2023
pubmed:
30
3
2023
Statut:
epublish
Résumé
Nuclear factor erythroid 2-related factor 2 (Nrf2) is downregulated in chronic kidney disease (CKD). Activation of Nrf2 might be a therapeutic option in CKD. Here we investigate the effect of Nrf2 activation on aldosterone (Aldo)-induced renal injury. Wild-type (WT) mice, transgenic Keap1 hypomorphic (Nrf2ꜛ, genotype results in upregulation of Nrf2 expression) mice and WT mice treated with the Nrf2 activator sulforaphane (Sulf) received Aldo for 4 weeks. In Aldo-treated mice, kidneys were significantly heavier and pathologically altered, reflected by increased urinary albumin levels and tissue damage. In Nrf2ꜛ-Aldo mice the tubule damage marker NGAL was significantly decreased. Increased oxidative damage markers (8-OHdG, 15-isoprostane F
Identifiants
pubmed: 36979025
pii: antiox12030777
doi: 10.3390/antiox12030777
pmc: PMC10044832
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : Schu 2367/5-4
Références
Nephrol Dial Transplant. 2015 Mar;30(3):441-51
pubmed: 25271006
Free Radic Biol Med. 2015 Nov;88(Pt B):108-146
pubmed: 26122708
Nat Genet. 2003 Nov;35(3):238-45
pubmed: 14517554
Kidney Int. 2021 Jan;99(1):102-116
pubmed: 32818518
Antioxidants (Basel). 2022 Sep 20;11(10):
pubmed: 36290577
Genes Dev. 1999 Jan 1;13(1):76-86
pubmed: 9887101
Clin Cancer Res. 2012 Jun 15;18(12):3396-406
pubmed: 22634319
Mol Cell Biol. 2010 Jun;30(12):3016-26
pubmed: 20404090
J Am Soc Nephrol. 2009 Apr;20(4):730-41
pubmed: 19211714
N Engl J Med. 2011 Jul 28;365(4):327-36
pubmed: 21699484
J Biol Chem. 2000 May 19;275(20):15466-73
pubmed: 10747902
Nephrol Dial Transplant. 2014 Feb;29 Suppl 1:i19-i24
pubmed: 23761459
J Biol Chem. 2007 Jun 1;282(22):16502-10
pubmed: 17403689
Pharm Res. 2011 Dec;28(12):3171-9
pubmed: 21681606
Am J Respir Cell Mol Biol. 2007 Feb;36(2):166-74
pubmed: 16990612
Mol Cell Biol. 2005 Sep;25(18):8044-51
pubmed: 16135796
J Cell Biochem. 2018 Jul;119(7):5934-5943
pubmed: 29600538
Redox Biol. 2019 Sep;26:101275
pubmed: 31349118
Antioxid Redox Signal. 2014 Nov 20;21(15):2126-42
pubmed: 24512358
Biochem Biophys Res Commun. 1997 Jul 18;236(2):313-22
pubmed: 9240432
Nephrol Dial Transplant. 2022 Aug 24;:
pubmed: 36002026
Am J Physiol Renal Physiol. 2010 Mar;298(3):F662-71
pubmed: 20007347
Sci Rep. 2016 Nov 02;6:36185
pubmed: 27804998
Br J Nutr. 2008 Mar;99(3):559-64
pubmed: 17868493
J Biol Chem. 2003 Nov 7;278(45):44675-82
pubmed: 12947090
Biochem Biophys Res Commun. 2006 Jan 6;339(1):79-88
pubmed: 16293230
Kidney Int. 2017 Feb;91(2):387-401
pubmed: 27789056
Oncogene. 2013 Aug 8;32(32):3765-81
pubmed: 22964642
J Biol Chem. 2002 Nov 8;277(45):42769-74
pubmed: 12198130
N Engl J Med. 2013 Dec 26;369(26):2492-503
pubmed: 24206459
Kidney Int Rep. 2020 Apr 14;5(6):879-890
pubmed: 32518870
Hypertension. 2008 Jul;52(1):123-9
pubmed: 18504326
Clin Kidney J. 2016 Feb;9(1):39-47
pubmed: 26798459
J Pharmacol Exp Ther. 2004 Jul;310(1):263-71
pubmed: 14988420
Antioxid Redox Signal. 2018 Dec 10;29(17):1727-1745
pubmed: 28899199
Redox Biol. 2018 May;15:405-417
pubmed: 29353218
J Nutr Biochem. 2015 Jun;26(6):596-606
pubmed: 25724107
J Hypertens. 2013 Feb;31(2):333-44
pubmed: 23249827
Mol Cell Biol. 2012 Sep;32(17):3486-99
pubmed: 22751928
J Physiol. 1998 Jun 1;509 ( Pt 2):599-606
pubmed: 9575307
Oxid Med Cell Longev. 2019 Jul 14;2019:9372182
pubmed: 31396308
BMC Nephrol. 2016 Aug 02;17(1):110
pubmed: 27484495
Biochem Pharmacol. 2013 Mar 15;85(6):705-17
pubmed: 23219527
Am J Nephrol. 2013;37(3):208-11
pubmed: 23466901
Free Radic Biol Med. 2009 Nov 1;47(9):1304-9
pubmed: 19666107
Free Radic Biol Med. 2015 Sep;86:374-81
pubmed: 25930007
Antioxidants (Basel). 2020 Aug 07;9(8):
pubmed: 32784785
Basic Clin Pharmacol Toxicol. 2018 Jan;122(1):65-73
pubmed: 28561324
Nat Methods. 2012 Jul;9(7):671-5
pubmed: 22930834
Kidney Int. 2014 Jan;85(1):134-41
pubmed: 24088953
Proc Natl Acad Sci U S A. 1992 Mar 15;89(6):2399-403
pubmed: 1549603
Int J Mol Sci. 2020 Jun 30;21(13):
pubmed: 32630085
J Nephrol. 2015 Aug;28(4):495-501
pubmed: 25585822
Hypertens Res. 2018 Jan;41(1):8-17
pubmed: 28978980