Epigenome-Wide Association Studies of the Fractional Exhaled Nitric Oxide and Bronchodilator Drug Response in Moderate-to-Severe Pediatric Asthma.
BDR
FeNO
asthma
biomarker
epigenetic
methylation
precision medicine
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
23 Feb 2023
23 Feb 2023
Historique:
received:
19
01
2023
revised:
14
02
2023
accepted:
18
02
2023
medline:
30
3
2023
entrez:
29
3
2023
pubmed:
30
3
2023
Statut:
epublish
Résumé
Asthma is the most prevalent pediatric chronic disease. Bronchodilator drug response (BDR) and fractional exhaled nitric oxide (FeNO) are clinical biomarkers of asthma. Although DNA methylation (DNAm) contributes to asthma pathogenesis, the influence of DNAm on BDR and FeNO is scarcely investigated. This study aims to identify DNAm markers in whole blood associated either with BDR or FeNO in pediatric asthma. We analyzed 121 samples from children with moderate-to-severe asthma. The association of genome-wide DNAm with BDR and FeNO has been assessed using regression models, adjusting for age, sex, ancestry, and tissue heterogeneity. Cross-tissue validation was assessed in 50 nasal samples. Differentially methylated regions (DMRs) and enrichment in traits and biological pathways were assessed. A false discovery rate (FDR) < 0.1 and a genome-wide significance threshold of
Identifiants
pubmed: 36979655
pii: biomedicines11030676
doi: 10.3390/biomedicines11030676
pmc: PMC10044864
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Spanish Ministry of Science and Innovation (MCIN)
ID : PID2020-116274RB-I00
Organisme : ZonMw
ID : project No. 9003035001
Pays : Netherlands
Organisme : Ministry of Education, Science, and Sport of the Republic of Slovenia
ID : contract No. C330-16-500106
Organisme : German Ministry of Education and Research (BMBF)
ID : project No. FKZ 031L0088
Organisme : Instituto de Salud Carlos III (ISCIII)
ID : award No. AC15/00015 and AC15/00058
Organisme : Ramón y Cajal Program
ID : RYC-2015-17205
Organisme : Spanish Ministry of Universities
ID : FPU19/02175
Organisme : MCIN/AEI/10.13039/501100011033 and the European Social Fund "Investing in your future"
ID : PRE2018-083837
Organisme : European Regional Development Fund
ID : CB06/06/1088
Organisme : Slovenian Research Agency
ID : No. P3-0427
Références
Int J Biol Sci. 2012;8(9):1281-90
pubmed: 23136556
Environ Health. 2021 Feb 11;20(1):12
pubmed: 33573660
PLoS One. 2014 Jul 10;9(7):e102356
pubmed: 25010197
Respir Res. 2020 Jan 10;21(1):14
pubmed: 31924195
Bioinformatics. 2012 Nov 15;28(22):2986-8
pubmed: 22954632
J Allergy Clin Immunol Pract. 2022 Apr;10(4):963-971.e3
pubmed: 35150902
Nucleic Acids Res. 2022 Jan 7;50(D1):D1004-D1009
pubmed: 34718752
Nat Commun. 2019 Jul 12;10(1):3095
pubmed: 31300640
Clin Epigenetics. 2018 Jun 1;10:73
pubmed: 29881472
Clin Exp Allergy. 2021 Aug;51(8):992-1005
pubmed: 33887082
Nucleic Acids Res. 2016 Jul 8;44(W1):W90-7
pubmed: 27141961
Bioinformatics. 2016 Sep 1;32(17):2659-63
pubmed: 27153672
Am J Respir Crit Care Med. 2011 Jul 15;184(2):191-7
pubmed: 21512169
Eur Respir J. 2007 Feb;29(2):292-8
pubmed: 17079261
Curr Opin Pharmacol. 2020 Apr;51:50-58
pubmed: 32836013
J Pers Med. 2021 May 28;11(6):
pubmed: 34071272
JCI Insight. 2017 Nov 2;2(21):
pubmed: 29093264
Allergy. 2004 May;59(5):469-78
pubmed: 15080825
Eur Respir J. 2019 Apr 4;53(4):
pubmed: 30765504
Nucleic Acids Res. 2016 Feb 18;44(3):e20
pubmed: 26384415
Methods Mol Biol. 2018;1708:303-330
pubmed: 29224151
BMC Genomics. 2019 May 14;20(1):366
pubmed: 31088362
Am J Respir Crit Care Med. 2005 Apr 15;171(8):912-30
pubmed: 15817806
Epigenetics. 2016;11(1):36-48
pubmed: 26786415
Epigenetics Chromatin. 2015 Jan 27;8:6
pubmed: 25972926
Am J Respir Crit Care Med. 2007 Dec 1;176(11):1072-8
pubmed: 17901411
J Allergy Clin Immunol. 2019 Jun;143(6):2263-2270.e14
pubmed: 30738172
J Allergy Clin Immunol. 2022 Nov 14;:
pubmed: 36395984
Pharmacol Ther. 2009 Jan;121(1):1-13
pubmed: 18950657
Nat Methods. 2016 May;13(5):443-5
pubmed: 27018579
Drug Des Devel Ther. 2018 Feb 12;12:281-293
pubmed: 29483769
BMC Genomics. 2017 Jan 3;18(1):4
pubmed: 28049437
Nucleic Acids Res. 2015 Apr 20;43(7):e47
pubmed: 25605792
Genome Biol. 2016 Oct 7;17(1):208
pubmed: 27717381
Eur Respir J. 2005 Aug;26(2):319-38
pubmed: 16055882
Clin Epigenetics. 2022 Jan 15;14(1):9
pubmed: 35033200
Immun Inflamm Dis. 2018 Jun;6(2):221-233
pubmed: 29314730
Clin Exp Allergy. 2019 Jul;49(7):953-968
pubmed: 31009112
Front Pediatr. 2018 Jun 19;6:170
pubmed: 29971223
Mol Cell Biol. 2019 Sep 11;39(19):
pubmed: 31285272
Eur Respir Rev. 2021 Nov 17;30(162):
pubmed: 34789462
Am J Respir Crit Care Med. 2004 Feb 1;169(3):386-92
pubmed: 14617512
Ann Am Thorac Soc. 2016 Mar;13 Suppl 1:S85-90
pubmed: 27027959
PPAR Res. 2020 Jan 14;2020:8906968
pubmed: 32395125
Nat Biotechnol. 2010 May;28(5):495-501
pubmed: 20436461
J Biol Chem. 2011 Sep 23;286(38):32891-7
pubmed: 21799019
Am J Respir Crit Care Med. 2001 Mar;163(3 Pt 1):778-85
pubmed: 11254538
Front Pediatr. 2019 Feb 05;7:6
pubmed: 30805318
J Allergy Clin Immunol. 2016 May;137(5):1390-1397.e6
pubmed: 26792209
Biochemistry. 2007 Feb 13;46(6):1647-62
pubmed: 17279628
Br J Cancer. 2015 Feb 17;112(4):755-64
pubmed: 25633035
J Am Board Fam Med. 2011 May-Jun;24(3):313-22
pubmed: 21551404
Curr Allergy Asthma Rep. 2021 Dec 27;21(12):47
pubmed: 34958416
Eur Respir J. 2016 Oct;48(4):1052-1062
pubmed: 27540019