The Third Dose of BNT162b2 COVID-19 Vaccine Does Not "Boost" Disease Flares and Adverse Events in Patients with Rheumatoid Arthritis.
COVID-19
SARS-CoV-2 vaccine
adverse events
autoimmune rheumatic diseases
disease flare
immunogenicity
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
23 Feb 2023
23 Feb 2023
Historique:
received:
21
01
2023
revised:
15
02
2023
accepted:
21
02
2023
medline:
30
3
2023
entrez:
29
3
2023
pubmed:
30
3
2023
Statut:
epublish
Résumé
Data on the risk of adverse events (AEs) and disease flares in autoimmune rheumatic diseases (ARDs) after the third dose of COVID-19 vaccine are scarce. The aim of this multicenter, prospective study is to analyze the clinical and immunological safety of BNT162b2 vaccine in a cohort of rheumatoid arthritis (RA) patients followed-up from the first vaccine cycle to the third dose. The vaccine showed an overall good safety profile with no patient reporting serious AEs, and a low percentage of total AEs at both doses (40/78 (51.3%) and 13/47 (27.7%) patients after the second and third dose, respectively (
Identifiants
pubmed: 36979666
pii: biomedicines11030687
doi: 10.3390/biomedicines11030687
pmc: PMC10045021
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Italian Ministry of Health, by the European Union's Horizon 2020 research and innovation pro-gramme under EVA GLOBAL grant
ID : 871029
Références
Ann Rheum Dis. 2022 Jul;81(7):1045-1048
pubmed: 35168944
Lancet Rheumatol. 2021 Aug;3(8):e542-e545
pubmed: 34179831
Ann Rheum Dis. 2021 Oct;80(10):1330-1338
pubmed: 34127481
Vaccines (Basel). 2022 May 26;10(6):
pubmed: 35746461
J Autoimmun. 2021 Dec;125:102743
pubmed: 34757289
Rheumatology (Oxford). 2022 Oct 31;:
pubmed: 36315075
Vaccines (Basel). 2021 Jul 02;9(7):
pubmed: 34358147
Arthritis Rheum. 2010 Sep;62(9):2569-81
pubmed: 20872595
Autoimmun Rev. 2022 Jan;21(1):102927
pubmed: 34474172
Cochrane Database Syst Rev. 2022 Dec 7;12:CD015477
pubmed: 36473651
Ann Rheum Dis. 2020 Jan;79(1):39-52
pubmed: 31413005
Rheumatol Int. 2021 Nov;41(11):1925-1931
pubmed: 34476603
Euro Surveill. 2022 Nov;27(45):
pubmed: 36367013
Biomedicines. 2021 Sep 04;9(9):
pubmed: 34572349
Front Immunol. 2022 Feb 28;13:846753
pubmed: 35309297
Vaccines (Basel). 2021 Jan 21;9(2):
pubmed: 33494477
JCI Insight. 2022 Jun 8;7(11):
pubmed: 35471956
Int Rev Immunol. 2010 Jun;29(3):247-69
pubmed: 20521925
Front Immunol. 2021 Sep 14;12:740249
pubmed: 34594343
Rheumatol Int. 2021 Aug;41(8):1441-1445
pubmed: 34142203
Ann Rheum Dis. 2022 Apr;81(4):564-568
pubmed: 34686479
Clin Exp Immunol. 2014 Jul;177(1):287-94
pubmed: 24666311
J Pers Med. 2021 Dec 02;11(12):
pubmed: 34945754
Int J Mol Sci. 2019 Dec 20;21(1):
pubmed: 31861764
Int J Infect Dis. 2022 Dec;125:195-208
pubmed: 36328289
Clin Immunol. 2017 Aug;181:60-66
pubmed: 28625884
Int Rev Immunol. 2010 Jun;29(3):270-314
pubmed: 20521926
Nat Rev Rheumatol. 2022 Apr;18(4):191-204
pubmed: 35217850
N Engl J Med. 2011 Dec 8;365(23):2205-19
pubmed: 22150039
Arthritis Rheum. 2002 Sep;46(9):2287-93
pubmed: 12355475
RMD Open. 2019 Jun 9;5(1):e000935
pubmed: 31245055
Biomedicines. 2022 Apr 01;10(4):
pubmed: 35453585
N Engl J Med. 2021 Dec 9;385(24):e84
pubmed: 34614326
Vaccines (Basel). 2022 Oct 20;10(10):
pubmed: 36298622
Rheumatol Int. 2022 Jan;42(1):31-39
pubmed: 34739573
Ann Rheum Dis. 2018 Sep;77(9):1283-1289
pubmed: 29886430
Ann Rheum Dis. 2020 Jul;79(7):851-858
pubmed: 32503854
Ann Rheum Dis. 2022 Mar;81(3):443-445
pubmed: 34824048
Arthritis Rheumatol. 2021 Oct;73(10):e60-e75
pubmed: 34346564
Front Microbiol. 2018 Jan 31;9:83
pubmed: 29445364
Clin Rheumatol. 2022 Oct;41(10):3199-3209
pubmed: 35760939
Pharmacol Res. 2015 Oct;100:190-209
pubmed: 26275795
RMD Open. 2021 Sep;7(3):
pubmed: 34493645
Biomedicines. 2021 Jan 09;9(1):
pubmed: 33435454
Front Immunol. 2022 Jul 04;13:919979
pubmed: 35860285
J Autoimmun. 2023 Jan;134:102959
pubmed: 36473406
Ann Rheum Dis. 2022 May;81(5):695-709
pubmed: 34972811
Lancet Rheumatol. 2021 Apr;3(4):e241-e243
pubmed: 33655220
Arthritis Rheumatol. 2022 Jan;74(1):28-32
pubmed: 34346185
ACR Open Rheumatol. 2021 Dec;3(12):832-833
pubmed: 34472714
Rheumatology (Oxford). 2022 Dec 23;62(1):467-472
pubmed: 35640110
PLoS Pathog. 2021 Oct 25;17(10):e1009928
pubmed: 34695164
Ann Rheum Dis. 2022 Jun;81(6):889-897
pubmed: 35193873
Arthritis Rheumatol. 2022 Aug;74(8):1321-1332
pubmed: 35507355
Arthritis Rheumatol. 2023 Jan;75(1):E1-E16
pubmed: 36345691
Rheumatology (Oxford). 2022 Jun 28;61(SI2):SI143-SI150
pubmed: 35460240
Arthritis Res Ther. 2022 Jan 11;24(1):21
pubmed: 35016701