An Artificial Placenta Experimental System in Sheep: Critical Issues for Successful Transition and Survival up to One Week.
artificial placenta
artificial womb
fetal lamb
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
24 Feb 2023
24 Feb 2023
Historique:
received:
09
02
2023
revised:
21
02
2023
accepted:
22
02
2023
medline:
30
3
2023
entrez:
29
3
2023
pubmed:
30
3
2023
Statut:
epublish
Résumé
To describe the development of an artificial placenta (AP) system in sheep with learning curve and main bottlenecks to allow survival up to one week. A total of 28 fetal sheep were transferred to an AP system at 110-115 days of gestation. The survival goal in the AP system was increased progressively in three consecutive study groups: 1-3 h (n = 8), 4-24 h (n = 10) and 48-168 h (n = 10). Duration of cannulation procedure, technical complications, pH, lactate, extracorporeal circulation (EC) circuit flows, fetal heart rate, and outcomes across experiments were compared. There was a progressive reduction in cannulation complications (75%, 50% and 0%, Achieving a reproducible experimental setting for an AP system is extremely challenging, time- and effort-consuming, and requires a highly multidisciplinary team. As a result of the learning curve, we achieved reproducible transition and survival up to 7 days. Extended survival requires improving instrumentation with custom-designed devices.
Identifiants
pubmed: 36979681
pii: biomedicines11030702
doi: 10.3390/biomedicines11030702
pmc: PMC10044909
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : "la Caixa" Banking Foundation
ID : N/A
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