Natural Course of COVID-19 and Independent Predictors of Mortality.
COVID-19
NT-pro-BNP
PaO2/FiO2
SARS-CoV-2
biomarkers
coronavirus disease
prothrombin time
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
17 Mar 2023
17 Mar 2023
Historique:
received:
28
02
2023
revised:
12
03
2023
accepted:
13
03
2023
medline:
30
3
2023
entrez:
29
3
2023
pubmed:
30
3
2023
Statut:
epublish
Résumé
During the SARS-CoV-2 pandemic, several biomarkers were shown to be helpful in determining the prognosis of COVID-19 patients. The aim of our study was to evaluate the prognostic value of N-terminal pro-Brain Natriuretic Peptide (NT-pro-BNP) in a cohort of patients with COVID-19. One-hundred and seven patients admitted to the Covid Hospital of Messina University between June 2022 and January 2023 were enrolled in our study. The demographic, clinical, biochemical, instrumental, and therapeutic parameters were recorded. The primary outcome was in-hospital mortality. A comparison between patients who recovered and were discharged and those who died during the hospitalization was performed. The independent parameters associated with in-hospital death were assessed by multivariable analysis and a stepwise regression logistic model. A total of 27 events with an in-hospital mortality rate of 25.2% occurred during our study. Those who died during hospitalization were older, with lower GCS and PaO This study shows that NT-pro-BNP levels, PT, and PaO
Sections du résumé
BACKGROUND
BACKGROUND
During the SARS-CoV-2 pandemic, several biomarkers were shown to be helpful in determining the prognosis of COVID-19 patients. The aim of our study was to evaluate the prognostic value of N-terminal pro-Brain Natriuretic Peptide (NT-pro-BNP) in a cohort of patients with COVID-19.
METHODS
METHODS
One-hundred and seven patients admitted to the Covid Hospital of Messina University between June 2022 and January 2023 were enrolled in our study. The demographic, clinical, biochemical, instrumental, and therapeutic parameters were recorded. The primary outcome was in-hospital mortality. A comparison between patients who recovered and were discharged and those who died during the hospitalization was performed. The independent parameters associated with in-hospital death were assessed by multivariable analysis and a stepwise regression logistic model.
RESULTS
RESULTS
A total of 27 events with an in-hospital mortality rate of 25.2% occurred during our study. Those who died during hospitalization were older, with lower GCS and PaO
CONCLUSIONS
CONCLUSIONS
This study shows that NT-pro-BNP levels, PT, and PaO
Identifiants
pubmed: 36979918
pii: biomedicines11030939
doi: 10.3390/biomedicines11030939
pmc: PMC10046319
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Nat Med. 2022 Feb;28(2):410-422
pubmed: 34907393
Heart. 2020 Oct;106(19):1512-1518
pubmed: 32817312
J Clin Med. 2023 Feb 25;12(5):
pubmed: 36902636
J Hypertens. 2022 Sep 1;40(9):1629-1638
pubmed: 35943095
ESC Heart Fail. 2021 Oct;8(5):4278-4287
pubmed: 34346182
Intensive Care Med. 2020 May;46(5):846-848
pubmed: 32125452
Acta Med Indones. 2021 Oct;53(4):385-396
pubmed: 35027485
Eur J Clin Microbiol Infect Dis. 2021 May;40(5):905-919
pubmed: 33389262
Medicina (Kaunas). 2022 Apr 11;58(4):
pubmed: 35454369
Eur J Heart Fail. 2022 Nov;24(11):2078-2089
pubmed: 35785461
Sci Rep. 2021 Apr 1;11(1):7334
pubmed: 33795768
Int J Infect Dis. 2021 Apr;105:551-559
pubmed: 33711519
Crit Care Med. 2017 Jan;45(1):e40-e48
pubmed: 27618274
Front Physiol. 2022 Jan 14;12:748972
pubmed: 35095546
Curr Med Res Opin. 2021 Jan;37(1):21-25
pubmed: 33210948
BMJ Open. 2015 Mar 27;5(3):e006812
pubmed: 25818272
Int J Cardiol. 2021 Mar 1;326:230-236
pubmed: 32979425
Int J Environ Res Public Health. 2019 Mar 28;16(7):
pubmed: 30925660
Lancet Respir Med. 2020 Apr;8(4):420-422
pubmed: 32085846
J Clin Med. 2020 Sep 12;9(9):
pubmed: 32932743
Rev Cardiovasc Med. 2022 Jan 17;23(1):28
pubmed: 35092220
Cardiovasc Res. 2023 Feb 3;118(18):3416-3433
pubmed: 36004816
J Clin Med. 2020 Jul 15;9(7):
pubmed: 32679766
Nature. 2020 Sep;585(7825):342-343
pubmed: 32934351
Biochem Genet. 2022 Dec;60(6):2052-2068
pubmed: 35235083
Theranostics. 2020 Jun 12;10(16):7448-7464
pubmed: 32642005
Respir Res. 2020 Apr 15;21(1):83
pubmed: 32293449
Euro Surveill. 2020 Apr;25(16):
pubmed: 32347201
Eur Heart J Acute Cardiovasc Care. 2021 May 11;10(3):310-319
pubmed: 33655301
J Res Med Sci. 2021 Nov 29;26:113
pubmed: 35126576
Crit Care Med. 2021 Nov 1;49(11):e1063-e1143
pubmed: 34605781
BMJ Open. 2020 Oct 10;10(10):e043651
pubmed: 33040020
APMIS. 2022 May;130(5):243-252
pubmed: 35114008
Front Med (Lausanne). 2021 Sep 30;8:719976
pubmed: 34660631
JAMA. 2012 Jun 20;307(23):2526-33
pubmed: 22797452
Immunol Lett. 2021 Jun;234:44-46
pubmed: 33905752
Eur Heart J. 2020 May 14;41(19):1821-1829
pubmed: 32383763
Eur Heart J. 2021 Sep 21;42(36):3599-3726
pubmed: 34447992
J Cardiovasc Magn Reson. 2021 Dec 30;23(1):140
pubmed: 34969397
Heart Fail Rev. 2021 Mar;26(2):363-369
pubmed: 33191474
J Thromb Haemost. 2020 May;18(5):1233-1234
pubmed: 32291954
Nat Rev Cardiol. 2021 Mar;18(3):169-193
pubmed: 33046850
Circulation. 2018 Sep 11;138(11):1088-1099
pubmed: 29764898