Leucine-Rich Alpha-2-Glycoprotein: A Novel Predictor of Diastolic Dysfunction.
biomarker
cross-sectional study
diastolic dysfunction
heart failure with preserved ejection fraction (HFpEF)
leucine-rich alpha-2-glycoprotein 1 (LRG1)
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
20 Mar 2023
20 Mar 2023
Historique:
received:
29
01
2023
revised:
12
03
2023
accepted:
14
03
2023
medline:
30
3
2023
entrez:
29
3
2023
pubmed:
30
3
2023
Statut:
epublish
Résumé
Leucine-rich α2-glycoprotein (LRG1) mediates cardiac fibrocyte activation. It is upregulated in inflammatory conditions, atherosclerosis, and fibrosis. Diastolic dysfunction (DD) is due to myocardial fibrosis. This cross-sectional study examined the relationship between LRG1 and DD. Patients with symptoms of chronic coronary ischemia were recruited. Patients with symptoms of overt heart failure, ejection fraction (EF) < 55%, impaired renal function, infection, and recent trauma were excluded from the study. Clinical parameters examined were SYNergy between percutaneous coronary intervention with TAXus and cardiac surgery (SYNTAX) score, echocardiographic assessment, and LRG1 levels. Binary stepwise logistic regression was used to evaluate the association between LRG1 and DD. Receiver Operating Characteristic (ROC) analysis was used to determine optimal cut-off values and predictive performance of LRG1. A total of 94 patients were enrolled in the study, with 47 having a clinical diagnosis of DD. Plasma LRG1 was significantly (U = 417.00,
Identifiants
pubmed: 36979923
pii: biomedicines11030944
doi: 10.3390/biomedicines11030944
pmc: PMC10045934
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ministry of Higher Education
ID : FRGS/1/2018/SKK02/USM/03/2
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