cRGD-Functionalized Silk Fibroin Nanoparticles: A Strategy for Cancer Treatment with a Potent Unselective Naphthalene Diimide Derivative.
NDI
RGD
active targeting
anticancer
brain tumours
cyclic pentapeptides
drug delivery
integrin antagonist
naphthalene diimides
silk fibroin nanoparticles
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
11 Mar 2023
11 Mar 2023
Historique:
received:
24
12
2022
revised:
03
02
2023
accepted:
07
03
2023
medline:
30
3
2023
entrez:
29
3
2023
pubmed:
30
3
2023
Statut:
epublish
Résumé
Developing drug delivery systems to target cytotoxic drugs directly into tumor cells is still a compelling need with regard to reducing side effects and improving the efficacy of cancer chemotherapy. In this work, silk fibroin nanoparticles (SFNs) have been designed to load a previously described cytotoxic compound (NDI-1) that disrupts the cell cycle by specifically interacting with non-canonical secondary structures of DNA. SFNs were then functionalized on their surface with cyclic pentapeptides incorporating the Arg-Gly-Asp sequence (
Identifiants
pubmed: 36980611
pii: cancers15061725
doi: 10.3390/cancers15061725
pmc: PMC10046852
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Italian Ministry of Health
ID : MINSAL_INVITRO_TUMOR, CUP E85F21003590001
Organisme : nterreg V-A Italy-Switzerland 2014-2020, ATEx-Advanced Therapies Experiences
ID : Project ID 3859153
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