Simultaneous Inhibition of Ceramide Hydrolysis and Glycosylation Synergizes to Corrupt Mitochondrial Respiration and Signal Caspase Driven Cell Death in Drug-Resistant Acute Myeloid Leukemia.
P-glycoprotein
acute myeloid leukemia
ceramide
chemotherapy resistance
sphingolipids
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
21 Mar 2023
21 Mar 2023
Historique:
received:
14
02
2023
revised:
10
03
2023
accepted:
15
03
2023
medline:
30
3
2023
entrez:
29
3
2023
pubmed:
30
3
2023
Statut:
epublish
Résumé
Acute myelogenous leukemia (AML), the most prevalent acute and aggressive leukemia diagnosed in adults, often recurs as a difficult-to-treat, chemotherapy-resistant disease. Because chemotherapy resistance is a major obstacle to successful treatment, novel therapeutic intervention is needed. Upregulated ceramide clearance via accelerated hydrolysis and glycosylation has been shown to be an element in chemotherapy-resistant AML, a problem considering the crucial role ceramide plays in eliciting apoptosis. Herein we employed agents that block ceramide clearance to determine if such a "reset" would be of therapeutic benefit. SACLAC was utilized to limit ceramide hydrolysis, and D-
Identifiants
pubmed: 36980769
pii: cancers15061883
doi: 10.3390/cancers15061883
pmc: PMC10046858
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIH HHS
ID : P01 CA171983
Pays : United States
Organisme : BLRD VA
ID : I01 BX001792
Pays : United States
Organisme : BLRD VA
ID : IK6 BX004603
Pays : United States
Organisme : BLRD VA
ID : I01 BX006063
Pays : United States
Organisme : NCI NIH HHS
ID : F31 CA271809
Pays : United States
Références
J Lipid Res. 2019 Sep;60(9):1590-1602
pubmed: 31363040
Leuk Lymphoma. 2017 Sep;58(9):1-17
pubmed: 28140720
Haematologica. 2010 May;95(5):819-28
pubmed: 19951971
Int J Biochem Cell Biol. 2012 Apr;44(4):620-8
pubmed: 22230369
Expert Opin Ther Targets. 2017 Jun;21(6):583-590
pubmed: 28434262
Biochim Biophys Acta. 2006 Dec;1758(12):1864-84
pubmed: 17052686
Free Radic Biol Med. 2016 Jul;96:273-89
pubmed: 27154977
Adv Cancer Res. 2018;140:235-263
pubmed: 30060811
Mol Cancer Ther. 2002 Jan;1(3):205-13
pubmed: 12467215
Blood. 2016 Oct 13;128(15):1944-1958
pubmed: 27540013
Cancer Chemother Pharmacol. 2001 May;47(5):444-50
pubmed: 11391861
Sci Rep. 2020 Oct 19;10(1):17599
pubmed: 33077793
Anticancer Agents Med Chem. 2011 Nov;11(9):891-903
pubmed: 21707483
Cell. 1995 Aug 11;82(3):405-14
pubmed: 7634330
Leuk Res. 2008 Mar;32(3):475-80
pubmed: 17709137
Int J Oncol. 2011 Mar;38(3):701-11
pubmed: 21186402
IUBMB Life. 2002 Nov;54(5):241-52
pubmed: 12587974
Onco Targets Ther. 2018 Oct 23;11:7301-7314
pubmed: 30425521
Nat Rev Cancer. 2013 Jan;13(1):51-65
pubmed: 23235911
J Biochem. 1992 Feb;111(2):191-6
pubmed: 1533217
J Biol Chem. 2000 Aug 18;275(33):25255-61
pubmed: 10837489
Annu Rev Pharmacol Toxicol. 2016;56:85-102
pubmed: 26514196
ACS Chem Neurosci. 2020 Oct 21;11(20):3464-3473
pubmed: 33035424
FASEB J. 2022 Jan;36(1):e22094
pubmed: 34888943
Elife. 2021 Jun 16;10:
pubmed: 34132194
FASEB J. 2001 Mar;15(3):719-30
pubmed: 11259390
Oncol Lett. 2018 May;15(5):6671-6677
pubmed: 29616130
Exp Cell Res. 2011 Jul 15;317(12):1736-45
pubmed: 21396934
Arch Pharm Res. 2019 Mar;42(3):232-243
pubmed: 30661200
Drug Resist Updat. 2012 Feb-Apr;15(1-2):62-9
pubmed: 22409994
J Biol Chem. 1997 Jan 17;272(3):1682-7
pubmed: 8999846
EMBO J. 1996 May 15;15(10):2417-24
pubmed: 8665849
J Lipid Res. 1987 May;28(5):565-71
pubmed: 2955067
Oncotarget. 2016 Dec 13;7(50):83208-83222
pubmed: 27825124
Cell. 1996 Nov 1;87(3):507-17
pubmed: 8898203
Cell Signal. 2021 Feb;78:109838
pubmed: 33212155
Cytometry A. 2020 Oct;97(10):1044-1051
pubmed: 32830910
Curr Top Med Chem. 2019;19(17):1512-1520
pubmed: 30827244
Biochem Pharmacol. 1992 Jan 9;43(1):109-17
pubmed: 1346494
Onco Targets Ther. 2019 May 01;12:3295-3304
pubmed: 31118680
J Bioenerg Biomembr. 2017 Feb;49(1):57-64
pubmed: 26801188
Mol Biol Cell. 2016 Jan 1;27(1):20-34
pubmed: 26538029
Cell Rep. 2018 Sep 25;24(13):3593-3606.e10
pubmed: 30257218
Clin Cancer Res. 2000 Mar;6(3):942-8
pubmed: 10741719
Biochim Biophys Acta. 2015 Sep;1851(9):1134-45
pubmed: 25964209
J Lipid Res. 2016 Jul;57(7):1231-42
pubmed: 27140664
Mol Cancer Ther. 2007 Feb;6(2):712-22
pubmed: 17308067
Int J Biochem Cell Biol. 2013 Jul;45(7):1195-203
pubmed: 23538298
J Lipid Res. 2021;62:100128
pubmed: 34597626
Blood Rev. 2020 Nov;44:100672
pubmed: 32204955
J Am Chem Soc. 2019 May 15;141(19):7736-7742
pubmed: 31030513
Mol Pharmacol. 2002 Aug;62(2):304-12
pubmed: 12130682
Mol Cancer Res. 2020 Mar;18(3):352-363
pubmed: 31744877
Mol Genet Metab. 2007 Jul;91(3):259-67
pubmed: 17509920
Int J Oncol. 2010 Dec;37(6):1591-7
pubmed: 21042729
Trans Am Clin Climatol Assoc. 2013;124:46-60
pubmed: 23874009
Biochem Pharmacol. 2017 Apr 15;130:21-33
pubmed: 28189725
Eur J Med Chem. 2021 Jan 15;210:113038
pubmed: 33333396
Biochem Biophys Res Commun. 2016 Apr 15;472(4):662-8
pubmed: 26920060