Elevated Baseline Neutrophil Count Correlates with Worse Outcomes in Patients with Muscle-Invasive Bladder Cancer Treated with Chemoradiation.
chemoradiation
inflammation
localized bladder cancer
neutrophil count
neutrophil-to-lymphocyte ratio
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
21 Mar 2023
21 Mar 2023
Historique:
received:
30
01
2023
revised:
08
03
2023
accepted:
20
03
2023
medline:
30
3
2023
entrez:
29
3
2023
pubmed:
30
3
2023
Statut:
epublish
Résumé
The role of inflammation in the development and prognosis of bladder cancer (BC) is now established. We evaluated the significance of neutrophil-to-lymphocyte ratio (NLR) and neutrophil count (PNN) in patients with localized BC treated with chemoradiation. Clinical characteristics and baseline biological data were retrospectively collected. We tested the association between NLR, PNN, and overall survival (OS) and progression-free survival (PFS). One hundred and ninety-four patients were included. Median PNN was 4000.0/mm Elevated PNN at baseline was associated with worse OS and PFS. NLR was not an independent prognostic factor.
Sections du résumé
BACKGROUND
BACKGROUND
The role of inflammation in the development and prognosis of bladder cancer (BC) is now established. We evaluated the significance of neutrophil-to-lymphocyte ratio (NLR) and neutrophil count (PNN) in patients with localized BC treated with chemoradiation.
METHODS
METHODS
Clinical characteristics and baseline biological data were retrospectively collected. We tested the association between NLR, PNN, and overall survival (OS) and progression-free survival (PFS).
RESULTS
RESULTS
One hundred and ninety-four patients were included. Median PNN was 4000.0/mm
CONCLUSIONS
CONCLUSIONS
Elevated PNN at baseline was associated with worse OS and PFS. NLR was not an independent prognostic factor.
Identifiants
pubmed: 36980771
pii: cancers15061886
doi: 10.3390/cancers15061886
pmc: PMC10047214
pii:
doi:
Types de publication
Journal Article
Langues
eng
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