Genome-Wide Analysis of Dental Caries Variability Reveals Genotype-by-Environment Interactions.
dental caries
genome-wide vQTL
genotype-by-environment interactions
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
17 03 2023
17 03 2023
Historique:
received:
04
02
2023
revised:
09
03
2023
accepted:
15
03
2023
medline:
30
3
2023
entrez:
29
3
2023
pubmed:
30
3
2023
Statut:
epublish
Résumé
Genotype-by-environment interactions (GEI) may influence dental caries, although their effects are difficult to detect. Variance quantitative trait loci (vQTL) may serve as an indicator of underlying GEI effects. The aim of this study was to investigate GEI effects on dental caries by prioritizing variants from genome-wide vQTL analysis. First, we identified vQTLs from ~4.3 M genome-wide variants in three cohorts of white children aged 3-5 (n = 396, n = 328, n = 773) using Levene's test. A total of 39 independent vQTLs with
Identifiants
pubmed: 36981009
pii: genes14030736
doi: 10.3390/genes14030736
pmc: PMC10048401
pii:
doi:
Substances chimiques
SLC5A8 protein, human
0
Monocarboxylic Acid Transporters
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : R01-DE014899, 1-U01-DE018903, X01-HG009878, R01-DE09551, and P30-DE10126.
Pays : United States
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