Protective Effect of Ergothioneine against 7-Ketocholesterol-Induced Mitochondrial Damage in hCMEC/D3 Human Brain Endothelial Cells.
7-ketocholesterol
cytoprotection
ergothioneine
oxysterols
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
13 Mar 2023
13 Mar 2023
Historique:
received:
20
01
2023
revised:
06
03
2023
accepted:
07
03
2023
medline:
30
3
2023
entrez:
29
3
2023
pubmed:
30
3
2023
Statut:
epublish
Résumé
Recent findings have suggested that the natural compound ergothioneine (ET), which is synthesised by certain fungi and bacteria, has considerable cytoprotective potential. We previously demonstrated the anti-inflammatory effects of ET on 7-ketocholesterol (7KC)-induced endothelial injury in human blood-brain barrier endothelial cells (hCMEC/D3). 7KC is an oxidised form of cholesterol present in atheromatous plaques and the sera of patients with hypercholesterolaemia and diabetes mellitus. The aim of this study was to elucidate the protective effect of ET on 7KC-induced mitochondrial damage. Exposure of human brain endothelial cells to 7KC led to a loss of cell viability, together with an increase in intracellular free calcium levels, increased cellular and mitochondrial reactive oxygen species, a decrease in mitochondrial membrane potential, reductions in ATP levels, and increases in mRNA expression of
Identifiants
pubmed: 36982572
pii: ijms24065498
doi: 10.3390/ijms24065498
pmc: PMC10056831
pii:
doi:
Substances chimiques
7-ketocholesterol
O7676FE78M
Ergothioneine
BDZ3DQM98W
Ketocholesterols
0
RNA, Messenger
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
Brain Pathol. 2003 Jul;13(3):250-62
pubmed: 12946016
Mol Neurobiol. 2010 Jun;41(2-3):299-313
pubmed: 20140539
Kidney Int. 2017 Dec;92(6):1356-1369
pubmed: 28754554
Int J Mol Sci. 2021 Jul 19;22(14):
pubmed: 34299328
J Cell Mol Med. 2010 May;14(5):1101-12
pubmed: 19438816
J Mol Cell Cardiol. 2005 Nov;39(5):823-32
pubmed: 16198370
Diabetes Res Clin Pract. 2008 Apr;80(1):63-8
pubmed: 18207277
Biochem Biophys Res Commun. 2016 Feb 5;470(2):245-250
pubmed: 26772879
J Alzheimers Dis. 2017;60(4):1223-1229
pubmed: 28946565
J Physiol. 2000 Nov 15;529 Pt 1:57-68
pubmed: 11080251
J Biol Chem. 2006 Jan 6;281(1):324-33
pubmed: 16230352
Neurosci Lett. 2010 May 26;476(1):36-41
pubmed: 20380872
Arch Biochem Biophys. 1991 Jul;288(1):10-6
pubmed: 1654816
Am J Pathol. 2018 Dec;188(12):2948-2959
pubmed: 30273598
Exp Neurol. 2016 Nov;285(Pt A):72-81
pubmed: 27632900
Mol Immunol. 2002 Feb;38(10):713-21
pubmed: 11841831
FASEB J. 2005 Nov;19(13):1872-4
pubmed: 16141364
Front Aging Neurosci. 2018 Oct 05;10:301
pubmed: 30344487
Diabetes Metab J. 2021 Nov;45(6):853-865
pubmed: 34847642
Free Radic Biol Med. 2016 Jul;96:211-22
pubmed: 27101740
Prog Neurobiol. 2014 Jun;117:20-40
pubmed: 24548606
J Steroid Biochem Mol Biol. 2017 May;169:96-110
pubmed: 27020660
Cell Calcium. 1999 Jan;25(1):19-28
pubmed: 10191957
Endothelium. 2006 May-Jun;13(3):213-26
pubmed: 16840177
Clin Hemorheol Microcirc. 2011;49(1-4):315-22
pubmed: 22214703
J Endocrinol Invest. 2019 Jan;42(1):7-17
pubmed: 29564756
Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):865-77
pubmed: 20175987
Redox Biol. 2019 Feb;21:101059
pubmed: 30576920
Atherosclerosis. 2000 Mar;149(1):191-7
pubmed: 10704631
J Pharmacol Exp Ther. 2014 Sep;350(3):691-700
pubmed: 25022513
Anal Biochem. 2002 Jul 15;306(2):323-7
pubmed: 12123672
Redox Biol. 2017 Oct;13:336-344
pubmed: 28633109
Biochem Biophys Res Commun. 1999 Apr 29;258(1):44-9
pubmed: 10222232
Int J Biochem Cell Biol. 1999 Mar-Apr;31(3-4):369-75
pubmed: 10224662
NPJ Regen Med. 2020 Nov 23;5(1):22
pubmed: 33298971
Biochem Biophys Res Commun. 2014 Apr 11;446(3):687-91
pubmed: 24275140
Cells. 2020 Oct 23;9(11):
pubmed: 33114025
Neuromolecular Med. 2022 Oct 19;:
pubmed: 36261765
Invest Ophthalmol Vis Sci. 2010 Feb;51(2):1164-70
pubmed: 19834037
Arterioscler Thromb Vasc Biol. 1999 May;19(5):1190-200
pubmed: 10323769
Redox Biol. 2016 Dec;10:24-33
pubmed: 27687218
Free Radic Res. 2016;50(1):14-25
pubmed: 26634964
J Neurosci Res. 1998 Feb 1;51(3):293-308
pubmed: 9486765
Molecules. 2020 May 13;25(10):
pubmed: 32414101
Antioxidants (Basel). 2021 May 31;10(6):
pubmed: 34073115
PLoS One. 2011 Feb 28;6(2):e17299
pubmed: 21387008
Invest Ophthalmol Vis Sci. 2010 Oct;51(10):4942-55
pubmed: 20554621
Nat Metab. 2022 Jun;4(6):651-662
pubmed: 35760871
Nat Rev Mol Cell Biol. 2003 Jul;4(7):552-65
pubmed: 12838338
Front Cell Dev Biol. 2020 Dec 21;8:597423
pubmed: 33409276
Neuromolecular Med. 2021 Mar;23(1):184-198
pubmed: 33067719
Biochem Biophys Res Commun. 2016 Sep 9;478(1):162-167
pubmed: 27444382
J Med Food. 2010 Dec;13(6):1340-6
pubmed: 21091247
J Biol Chem. 2014 Aug 22;289(34):23712-22
pubmed: 24973215
Annu Rev Food Sci Technol. 2023 Mar 27;14:323-345
pubmed: 36623925
Biochim Biophys Acta. 2014 Sep;1842(9):1806-15
pubmed: 24997450
Steroids. 2021 Aug;172:108854
pubmed: 33930389
Chem Res Toxicol. 2011 Jan 14;24(1):30-4
pubmed: 21047085
Mitochondrion. 2013 Mar;13(2):106-18
pubmed: 23333405
Redox Biol. 2020 Jan;29:101380
pubmed: 31926618
Antioxidants (Basel). 2022 Aug 30;11(9):
pubmed: 36139790
Eur J Pharmacol. 2006 Sep 28;546(1-3):11-8
pubmed: 16919261
Int J Mol Sci. 2020 Jul 06;21(13):
pubmed: 32640524
Free Radic Biol Med. 2017 Jul;108:8-18
pubmed: 28300670
Biochim Biophys Acta. 2012 May;1822(5):784-93
pubmed: 22001064
FEBS Lett. 2018 Oct;592(20):3357-3366
pubmed: 29851075
Fluids Barriers CNS. 2013 Mar 26;10(1):16
pubmed: 23531482
Front Immunol. 2020 Feb 20;11:202
pubmed: 32153568
Arch Pharm Res. 2016 Nov;39(11):1503-1518
pubmed: 27600432